6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification
6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO)-induced liver injury remains unclear. The network pharmacol...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623001512 |
| _version_ | 1797819894186639360 |
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| author | Yongchao Wu Xiaoqi Sun Haoying Li Xi Chu Yucong Xue Jiaying Qi Qingzhong Jia Xue Han Li Chu Shengjiang Guan Xiangting Wang |
| author_facet | Yongchao Wu Xiaoqi Sun Haoying Li Xi Chu Yucong Xue Jiaying Qi Qingzhong Jia Xue Han Li Chu Shengjiang Guan Xiangting Wang |
| author_sort | Yongchao Wu |
| collection | DOAJ |
| description | 6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO)-induced liver injury remains unclear. The network pharmacology and animal experiment results respectively indicated that oxidative stress and inflammatory responses were closely related to ATO-induced liver injury. 6G can alleviate ATO-induced liver injury and oxidative stress. Furthermore, 6G can attenuate the release of pro-inflammatory factors induced by ATO and reduce the expressions of NLRP3, ASC, Caspase-1 and gasdermin-D. The results showed that the activation of NLRP3 inflammatory and its induced pyroptosis play critical roles in liver injury caused by ATO. Furthermore, 6G can suppress the ROS-NLRP3 inflammasome signaling pathway, which may be an effective strategy for the treatment of ATO-induced liver injury. |
| first_indexed | 2024-03-13T09:29:21Z |
| format | Article |
| id | doaj.art-97eb9e9e3d6c4f6ea556eb0e840e1045 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-13T09:29:21Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-97eb9e9e3d6c4f6ea556eb0e840e10452023-05-26T04:21:09ZengElsevierJournal of Functional Foods1756-46462023-06-011051055516-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verificationYongchao Wu0Xiaoqi Sun1Haoying Li2Xi Chu3Yucong Xue4Jiaying Qi5Qingzhong Jia6Xue Han7Li Chu8Shengjiang Guan9Xiangting Wang10The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaThe Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Shijiazhuang, Hebei, ChinaSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Shijiazhuang, Hebei, China; Corresponding authors at: School of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China (L.C.; X.W.) and Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China (S.G.).Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; School of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; Corresponding authors at: School of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China (L.C.; X.W.) and Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China (S.G.).Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns, Shijiazhuang, Hebei, China; School of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China; Corresponding authors at: School of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China (L.C.; X.W.) and Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China (S.G.).6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO)-induced liver injury remains unclear. The network pharmacology and animal experiment results respectively indicated that oxidative stress and inflammatory responses were closely related to ATO-induced liver injury. 6G can alleviate ATO-induced liver injury and oxidative stress. Furthermore, 6G can attenuate the release of pro-inflammatory factors induced by ATO and reduce the expressions of NLRP3, ASC, Caspase-1 and gasdermin-D. The results showed that the activation of NLRP3 inflammatory and its induced pyroptosis play critical roles in liver injury caused by ATO. Furthermore, 6G can suppress the ROS-NLRP3 inflammasome signaling pathway, which may be an effective strategy for the treatment of ATO-induced liver injury.http://www.sciencedirect.com/science/article/pii/S17564646230015126-gingerolArsenic trioxideLiver injuryNetwork pharmacologyPyroptosisInflammation |
| spellingShingle | Yongchao Wu Xiaoqi Sun Haoying Li Xi Chu Yucong Xue Jiaying Qi Qingzhong Jia Xue Han Li Chu Shengjiang Guan Xiangting Wang 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification Journal of Functional Foods 6-gingerol Arsenic trioxide Liver injury Network pharmacology Pyroptosis Inflammation |
| title | 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification |
| title_full | 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification |
| title_fullStr | 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification |
| title_full_unstemmed | 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification |
| title_short | 6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification |
| title_sort | 6 gingerol attenuates arsenic trioxide induced liver injury by inhibiting pyroptosis and ros nlrp3 inflammatory signaling pathway based on network pharmacology analysis and experiment verification |
| topic | 6-gingerol Arsenic trioxide Liver injury Network pharmacology Pyroptosis Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623001512 |
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