6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification

6-Gingerol attenuates arsenic trioxide-induced liver injury by inhibiting pyroptosis and ROS-NLRP3 inflammatory signaling pathway: Based on network pharmacology analysis and experiment verification

6-Gingerol (6G) is the main phenolic active component of ginger, which has a certain protective effect against liver injury induced by drugs, and chemical pollutants. However, the mechanism of protection of 6G against arsenic trioxide (ATO)-induced liver injury remains unclear. The network pharmacol...

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Bibliographic Details
Main Authors: Yongchao Wu, Xiaoqi Sun, Haoying Li, Xi Chu, Yucong Xue, Jiaying Qi, Qingzhong Jia, Xue Han, Li Chu, Shengjiang Guan, Xiangting Wang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Journal of Functional Foods
Subjects:
6-gingerol
Arsenic trioxide
Liver injury
Network pharmacology
Pyroptosis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623001512

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