Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer
Leptin is a peptide hormone, mainly known for its role as a mediator of adipose tissue endocrine functions, such as appetite control and energy homeostasis. In addition, leptin signaling is involved in several physiological processes as modulation of innate and adaptive immune responses and regulati...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1394 |
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| author | Roberto Buonaiuto Fabiana Napolitano Sara Parola Pietro De Placido Valeria Forestieri Giovanna Pecoraro Alberto Servetto Luigi Formisano Pietro Formisano Mario Giuliano Grazia Arpino Sabino De Placido Carmine De Angelis |
| author_facet | Roberto Buonaiuto Fabiana Napolitano Sara Parola Pietro De Placido Valeria Forestieri Giovanna Pecoraro Alberto Servetto Luigi Formisano Pietro Formisano Mario Giuliano Grazia Arpino Sabino De Placido Carmine De Angelis |
| author_sort | Roberto Buonaiuto |
| collection | DOAJ |
| description | Leptin is a peptide hormone, mainly known for its role as a mediator of adipose tissue endocrine functions, such as appetite control and energy homeostasis. In addition, leptin signaling is involved in several physiological processes as modulation of innate and adaptive immune responses and regulation of sex hormone levels. When adipose tissue expands, an imbalance of adipokines secretion may occur and increasing leptin levels contribute to promoting a chronic inflammatory state, which is largely acknowledged as a hallmark of cancer. Indeed, upon binding its receptor (LEPR), leptin activates several oncogenic pathways, such as JAK/STAT, MAPK, and PI3K/AKT, and seems to affect cancer immune response by inducing a proinflammatory immune polarization and eventually enhancing T-cell exhaustion. In particular, obesity-associated hyperleptinemia has been related to breast cancer risk development, although the underlying mechanism is yet to be completely clarified and needs to be deemed in light of multiple variables, such as menopausal state and immune response. The aim of this review is to provide an overview of the potential role of leptin as a bridge between obesity and breast cancer and to establish the physio-pathological basis of the linkage between these major health concerns in order to identify appropriate and novel therapeutic strategies to adopt in daily clinical practice. |
| first_indexed | 2024-03-09T20:37:08Z |
| format | Article |
| id | doaj.art-97ebd0b383bb449b9155ecada5c474b9 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:37:08Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-97ebd0b383bb449b9155ecada5c474b92023-11-23T23:07:56ZengMDPI AGBiomolecules2218-273X2022-09-011210139410.3390/biom12101394Insight on the Role of Leptin: A Bridge from Obesity to Breast CancerRoberto Buonaiuto0Fabiana Napolitano1Sara Parola2Pietro De Placido3Valeria Forestieri4Giovanna Pecoraro5Alberto Servetto6Luigi Formisano7Pietro Formisano8Mario Giuliano9Grazia Arpino10Sabino De Placido11Carmine De Angelis12Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medicine, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyLeptin is a peptide hormone, mainly known for its role as a mediator of adipose tissue endocrine functions, such as appetite control and energy homeostasis. In addition, leptin signaling is involved in several physiological processes as modulation of innate and adaptive immune responses and regulation of sex hormone levels. When adipose tissue expands, an imbalance of adipokines secretion may occur and increasing leptin levels contribute to promoting a chronic inflammatory state, which is largely acknowledged as a hallmark of cancer. Indeed, upon binding its receptor (LEPR), leptin activates several oncogenic pathways, such as JAK/STAT, MAPK, and PI3K/AKT, and seems to affect cancer immune response by inducing a proinflammatory immune polarization and eventually enhancing T-cell exhaustion. In particular, obesity-associated hyperleptinemia has been related to breast cancer risk development, although the underlying mechanism is yet to be completely clarified and needs to be deemed in light of multiple variables, such as menopausal state and immune response. The aim of this review is to provide an overview of the potential role of leptin as a bridge between obesity and breast cancer and to establish the physio-pathological basis of the linkage between these major health concerns in order to identify appropriate and novel therapeutic strategies to adopt in daily clinical practice.https://www.mdpi.com/2218-273X/12/10/1394leptinLEPRobesitybreast cancer |
| spellingShingle | Roberto Buonaiuto Fabiana Napolitano Sara Parola Pietro De Placido Valeria Forestieri Giovanna Pecoraro Alberto Servetto Luigi Formisano Pietro Formisano Mario Giuliano Grazia Arpino Sabino De Placido Carmine De Angelis Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer Biomolecules leptin LEPR obesity breast cancer |
| title | Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer |
| title_full | Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer |
| title_fullStr | Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer |
| title_full_unstemmed | Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer |
| title_short | Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer |
| title_sort | insight on the role of leptin a bridge from obesity to breast cancer |
| topic | leptin LEPR obesity breast cancer |
| url | https://www.mdpi.com/2218-273X/12/10/1394 |
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