Rutaecarpine analogues with potent anti-inflammation to alleviate acute ulcerative colitis via regulating TLR4/MAPK/NF-κB pathway

Rutaecarpine analogues with potent anti-inflammation to alleviate acute ulcerative colitis via regulating TLR4/MAPK/NF-κB pathway

Natural products are a rich resource in drug discovery. In the report, series novel rutaecarpine-derived compounds with potent anti-inflammatory activity and therapeutic efficacy against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) were designed and synthesized. Thirty-two target com...

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Bibliographic Details
Main Authors: Li-Qing Qin, Zi-Yu Gu, Nan-Ying Chen, Pei-Dong Liu, Liu-Song Lan, Xin-Wei Li, Jun-Cheng Su, Gui-Fa Su, Dong-Liang Mo, Cheng-Xue Pan
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Rutaecarpine analogues
Anti-inflammation
Ulcerative colitis
TLR4/MAPK/NF-κB pathway
Structural modification
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624000262

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http://www.sciencedirect.com/science/article/pii/S2211715624000262

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