Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes
Currently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33721-y |
| _version_ | 1798029940805861376 |
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| author | Rupert L. Mayer Rein Verbeke Caroline Asselman Ilke Aernout Adillah Gul Denzel Eggermont Katie Boucher Fabien Thery Teresa M. Maia Hans Demol Ralf Gabriels Lennart Martens Christophe Bécavin Stefaan C. De Smedt Bart Vandekerckhove Ine Lentacker Francis Impens |
| author_facet | Rupert L. Mayer Rein Verbeke Caroline Asselman Ilke Aernout Adillah Gul Denzel Eggermont Katie Boucher Fabien Thery Teresa M. Maia Hans Demol Ralf Gabriels Lennart Martens Christophe Bécavin Stefaan C. De Smedt Bart Vandekerckhove Ine Lentacker Francis Impens |
| author_sort | Rupert L. Mayer |
| collection | DOAJ |
| description | Currently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice. |
| first_indexed | 2024-04-11T19:33:11Z |
| format | Article |
| id | doaj.art-97f012cb13b5447e97faef124f7e4dca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:33:11Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-97f012cb13b5447e97faef124f7e4dca2022-12-22T04:06:57ZengNature PortfolioNature Communications2041-17232022-10-0113111710.1038/s41467-022-33721-yImmunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenesRupert L. Mayer0Rein Verbeke1Caroline Asselman2Ilke Aernout3Adillah Gul4Denzel Eggermont5Katie Boucher6Fabien Thery7Teresa M. Maia8Hans Demol9Ralf Gabriels10Lennart Martens11Christophe Bécavin12Stefaan C. De Smedt13Bart Vandekerckhove14Ine Lentacker15Francis Impens16VIB-UGent Center for Medical Biotechnology, VIBGhent Research Group on Nanomedicines, Ghent UniversityVIB-UGent Center for Medical Biotechnology, VIBGhent Research Group on Nanomedicines, Ghent UniversityVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBVIB-UGent Center for Medical Biotechnology, VIBUniversité Côte d’Azur, CNRS, IPMCGhent Research Group on Nanomedicines, Ghent UniversityCancer Research Institute Ghent (CRIG)Ghent Research Group on Nanomedicines, Ghent UniversityVIB-UGent Center for Medical Biotechnology, VIBCurrently, no approved vaccines for Listeria monocytogenes are available. Here, the authors use immunopeptidomics to map bacterial peptides presented on infected cells and identify antigens that, as mRNA vaccine, provide protection in mice.https://doi.org/10.1038/s41467-022-33721-y |
| spellingShingle | Rupert L. Mayer Rein Verbeke Caroline Asselman Ilke Aernout Adillah Gul Denzel Eggermont Katie Boucher Fabien Thery Teresa M. Maia Hans Demol Ralf Gabriels Lennart Martens Christophe Bécavin Stefaan C. De Smedt Bart Vandekerckhove Ine Lentacker Francis Impens Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes Nature Communications |
| title | Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes |
| title_full | Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes |
| title_fullStr | Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes |
| title_full_unstemmed | Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes |
| title_short | Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes |
| title_sort | immunopeptidomics based design of mrna vaccine formulations against listeria monocytogenes |
| url | https://doi.org/10.1038/s41467-022-33721-y |
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