An Update on the Treatment of Papillary Renal Cell Carcinoma
Papillary renal cell carcinoma (pRCC) is the second-most common subtype of kidney cancer following clear cell renal cell carcinoma (ccRCC), representing 15% of kidney cancers. Despite advances in therapy, including combination strategies with targeted therapies and immune checkpoint inhibitors, prog...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/3/565 |
| _version_ | 1797625042825117696 |
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| author | Neal S. Chawla Nicolas Sayegh Sweta Prajapati Elyse Chan Sumanta K. Pal Alexander Chehrazi-Raffle |
| author_facet | Neal S. Chawla Nicolas Sayegh Sweta Prajapati Elyse Chan Sumanta K. Pal Alexander Chehrazi-Raffle |
| author_sort | Neal S. Chawla |
| collection | DOAJ |
| description | Papillary renal cell carcinoma (pRCC) is the second-most common subtype of kidney cancer following clear cell renal cell carcinoma (ccRCC), representing 15% of kidney cancers. Despite advances in therapy, including combination strategies with targeted therapies and immune checkpoint inhibitors, progress has lagged behind that of ccRCC. This is in part due to the heterogenous nature of the various subtypes of pRCC. More recently, investigators have turned efforts towards histology and biology-based trials. In this review, we outline some of the distinct biological characteristics of pRCC and discuss the most impactful clinical trials to date. Finally, we look ahead to several highly anticipated ongoing trials in pRCC. |
| first_indexed | 2024-03-11T09:51:14Z |
| format | Article |
| id | doaj.art-97f03124149f4c8685b04d30fd55e317 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:51:14Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-97f03124149f4c8685b04d30fd55e3172023-11-16T16:14:03ZengMDPI AGCancers2072-66942023-01-0115356510.3390/cancers15030565An Update on the Treatment of Papillary Renal Cell CarcinomaNeal S. Chawla0Nicolas Sayegh1Sweta Prajapati2Elyse Chan3Sumanta K. Pal4Alexander Chehrazi-Raffle5Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USADivision of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USADepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USADepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USADepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USADepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USAPapillary renal cell carcinoma (pRCC) is the second-most common subtype of kidney cancer following clear cell renal cell carcinoma (ccRCC), representing 15% of kidney cancers. Despite advances in therapy, including combination strategies with targeted therapies and immune checkpoint inhibitors, progress has lagged behind that of ccRCC. This is in part due to the heterogenous nature of the various subtypes of pRCC. More recently, investigators have turned efforts towards histology and biology-based trials. In this review, we outline some of the distinct biological characteristics of pRCC and discuss the most impactful clinical trials to date. Finally, we look ahead to several highly anticipated ongoing trials in pRCC.https://www.mdpi.com/2072-6694/15/3/565papillaryrenal cell carcinoma |
| spellingShingle | Neal S. Chawla Nicolas Sayegh Sweta Prajapati Elyse Chan Sumanta K. Pal Alexander Chehrazi-Raffle An Update on the Treatment of Papillary Renal Cell Carcinoma Cancers papillary renal cell carcinoma |
| title | An Update on the Treatment of Papillary Renal Cell Carcinoma |
| title_full | An Update on the Treatment of Papillary Renal Cell Carcinoma |
| title_fullStr | An Update on the Treatment of Papillary Renal Cell Carcinoma |
| title_full_unstemmed | An Update on the Treatment of Papillary Renal Cell Carcinoma |
| title_short | An Update on the Treatment of Papillary Renal Cell Carcinoma |
| title_sort | update on the treatment of papillary renal cell carcinoma |
| topic | papillary renal cell carcinoma |
| url | https://www.mdpi.com/2072-6694/15/3/565 |
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