Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge
<p>Abstract</p> <p>Aim</p> <p>This study attempted to distinguish primary bladder adenocarcinoma (PBA) from metastatic colonic adenocarcinomas (MCA), which is a difficult diagnostic and clinical problem.</p> <p>Methods</p> <p>Twenty-four cases of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-11-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://www.diagnosticpathology.org/content/7/1/151 |
| _version_ | 1818526520607506432 |
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| author | Roy Somak Smith Matthew A Cieply Kathy M Acquafondata Marie B Parwani Anil V |
| author_facet | Roy Somak Smith Matthew A Cieply Kathy M Acquafondata Marie B Parwani Anil V |
| author_sort | Roy Somak |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Aim</p> <p>This study attempted to distinguish primary bladder adenocarcinoma (PBA) from metastatic colonic adenocarcinomas (MCA), which is a difficult diagnostic and clinical problem.</p> <p>Methods</p> <p>Twenty-four cases of bladder adenocarcinomas (12 primary & 12 metastatic colorectal) were included in the study with urothelial carcinoma (UC) and colonic adenocarcinoma (CA) as controls. A panel of immunohistochemical (IHC) stains along with fluorescence in-situ hybridization (FISH), using the UroVysion probe set, was performed.</p> <p>Results</p> <p>The majority of the PBAs presented with advanced disease. Enteric histologic subtype was the most common morphological variant. Strong nuclear with cytoplasmic-membranous staining of β-catenin was seen in 75% of MCA and only 16.7% PBA (<10% staining cells). Although abnormal nuclear staining with E-cadherin was seen in both PBA and MCA, it was more frequent in former. CK-7, CK-20, villin and CDX-2 stains were not helpful in distinguishing the two entities. FISH did not reveal any unique differences in chromosomal abnormality between the two groups.</p> <p>Conclusion</p> <p>Although there was a statistically significant difference in β-catenin and E-cadherin staining between two groups, we did not find any IHC or FISH marker that was specific for PBA. Distinction between PBA and MCA remains a diagnostic problem and clinical correlation is vital before rendering a diagnosis.</p> <p>Virtual slides</p> <p>The virtual slides for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1393156268152357</url></p> |
| first_indexed | 2024-12-11T06:24:07Z |
| format | Article |
| id | doaj.art-97f0ffcb355e4874ac802a5ac3f54efa |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-11T06:24:07Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-97f0ffcb355e4874ac802a5ac3f54efa2022-12-22T01:17:44ZengBMCDiagnostic Pathology1746-15962012-11-017115110.1186/1746-1596-7-151Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challengeRoy SomakSmith Matthew ACieply Kathy MAcquafondata Marie BParwani Anil V<p>Abstract</p> <p>Aim</p> <p>This study attempted to distinguish primary bladder adenocarcinoma (PBA) from metastatic colonic adenocarcinomas (MCA), which is a difficult diagnostic and clinical problem.</p> <p>Methods</p> <p>Twenty-four cases of bladder adenocarcinomas (12 primary & 12 metastatic colorectal) were included in the study with urothelial carcinoma (UC) and colonic adenocarcinoma (CA) as controls. A panel of immunohistochemical (IHC) stains along with fluorescence in-situ hybridization (FISH), using the UroVysion probe set, was performed.</p> <p>Results</p> <p>The majority of the PBAs presented with advanced disease. Enteric histologic subtype was the most common morphological variant. Strong nuclear with cytoplasmic-membranous staining of β-catenin was seen in 75% of MCA and only 16.7% PBA (<10% staining cells). Although abnormal nuclear staining with E-cadherin was seen in both PBA and MCA, it was more frequent in former. CK-7, CK-20, villin and CDX-2 stains were not helpful in distinguishing the two entities. FISH did not reveal any unique differences in chromosomal abnormality between the two groups.</p> <p>Conclusion</p> <p>Although there was a statistically significant difference in β-catenin and E-cadherin staining between two groups, we did not find any IHC or FISH marker that was specific for PBA. Distinction between PBA and MCA remains a diagnostic problem and clinical correlation is vital before rendering a diagnosis.</p> <p>Virtual slides</p> <p>The virtual slides for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1393156268152357</url></p>http://www.diagnosticpathology.org/content/7/1/151BladderAdenocarcinomaPrimaryMetastaticColorectalBeta-cateninE-cadherin |
| spellingShingle | Roy Somak Smith Matthew A Cieply Kathy M Acquafondata Marie B Parwani Anil V Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge Diagnostic Pathology Bladder Adenocarcinoma Primary Metastatic Colorectal Beta-catenin E-cadherin |
| title | Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge |
| title_full | Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge |
| title_fullStr | Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge |
| title_full_unstemmed | Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge |
| title_short | Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge |
| title_sort | primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma a persisting diagnostic challenge |
| topic | Bladder Adenocarcinoma Primary Metastatic Colorectal Beta-catenin E-cadherin |
| url | http://www.diagnosticpathology.org/content/7/1/151 |
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