Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats
Abstract Background Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydr...
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BMC
2017-06-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2551-7 |
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| author | Patrick Amoateng Samuel Adjei Dorcas Osei-Safo Kennedy Kwami Edem Kukuia Irene Akwo Kretchy Joseph Adusei Sarkodie Benoit Banga N’Guessan |
| author_facet | Patrick Amoateng Samuel Adjei Dorcas Osei-Safo Kennedy Kwami Edem Kukuia Irene Akwo Kretchy Joseph Adusei Sarkodie Benoit Banga N’Guessan |
| author_sort | Patrick Amoateng |
| collection | DOAJ |
| description | Abstract Background Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydro-ethanolic extract in a rat model of paclitaxel-induced neuropathic pain. Methods Neuropathy was induced in rats by a continuous intraperitoneal administration of paclitaxel (2 mg/kg) for 5 days. Baseline latencies to thermal pain were recorded before the first injection of paclitaxel and during the 5 day induction period. Following the induction, the rats in designated treatment group were treated with the hydro-ethanolic extract (100, 300 and 1000 mg/kg, p.o) or pregabalin (10, 30 and 100 mg/kg) or vehicle (distilled water) and their responses to thermal hyperalgesia measured every 30 for a total period of 3 h. Results There was a significant difference between the baseline reaction latency and what was observed on the 5th day of the induction of neuropathy. Two days after the induction of neuropathy, the extract and pregabalin significantly and dose-dependently produced antinociceptive effect during the 3-h test period. Conclusion The hydro-ethanolic extract of the whole plant of Synedrella nodiflora possess analgesic effect in paclitaxel-induced neuropathy in rats. |
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| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-23T10:23:20Z |
| publishDate | 2017-06-01 |
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| series | BMC Research Notes |
| spelling | doaj.art-97f1d55f93ad4541b5fb7a15f401807a2022-12-21T17:50:39ZengBMCBMC Research Notes1756-05002017-06-011011710.1186/s13104-017-2551-7Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in ratsPatrick Amoateng0Samuel Adjei1Dorcas Osei-Safo2Kennedy Kwami Edem Kukuia3Irene Akwo Kretchy4Joseph Adusei Sarkodie5Benoit Banga N’Guessan6Department of Pharmacology & Toxicology, School of Pharmacy, College of Health Sciences, University of GhanaDepartment of Animal Experimentation, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartment of Chemistry, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of GhanaDepartment of Pharmacology & Toxicology, School of Pharmacy, College of Health Sciences, University of GhanaDepartment of Pharmacy Practice & Clinical Pharmacy, School of Pharmacy, College of Health Sciences, University of GhanaDepartment of Pharmacognosy & Herbal Medicine, School of Pharmacy, College of Health Sciences, University of GhanaDepartment of Pharmacology & Toxicology, School of Pharmacy, College of Health Sciences, University of GhanaAbstract Background Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydro-ethanolic extract in a rat model of paclitaxel-induced neuropathic pain. Methods Neuropathy was induced in rats by a continuous intraperitoneal administration of paclitaxel (2 mg/kg) for 5 days. Baseline latencies to thermal pain were recorded before the first injection of paclitaxel and during the 5 day induction period. Following the induction, the rats in designated treatment group were treated with the hydro-ethanolic extract (100, 300 and 1000 mg/kg, p.o) or pregabalin (10, 30 and 100 mg/kg) or vehicle (distilled water) and their responses to thermal hyperalgesia measured every 30 for a total period of 3 h. Results There was a significant difference between the baseline reaction latency and what was observed on the 5th day of the induction of neuropathy. Two days after the induction of neuropathy, the extract and pregabalin significantly and dose-dependently produced antinociceptive effect during the 3-h test period. Conclusion The hydro-ethanolic extract of the whole plant of Synedrella nodiflora possess analgesic effect in paclitaxel-induced neuropathy in rats.http://link.springer.com/article/10.1186/s13104-017-2551-7Synedrella nodifloraPregabalinPaclitaxelNeuropathicPain |
| spellingShingle | Patrick Amoateng Samuel Adjei Dorcas Osei-Safo Kennedy Kwami Edem Kukuia Irene Akwo Kretchy Joseph Adusei Sarkodie Benoit Banga N’Guessan Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats BMC Research Notes Synedrella nodiflora Pregabalin Paclitaxel Neuropathic Pain |
| title | Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats |
| title_full | Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats |
| title_fullStr | Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats |
| title_full_unstemmed | Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats |
| title_short | Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats |
| title_sort | analgesic effects of a hydro ethanolic whole plant extract of synedrella nodiflora l gaertn in paclitaxel induced neuropathic pain in rats |
| topic | Synedrella nodiflora Pregabalin Paclitaxel Neuropathic Pain |
| url | http://link.springer.com/article/10.1186/s13104-017-2551-7 |
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