Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide
Herein, we have reported on a simple, environmentally friendly, and ultra-sensitive electrode material, SnO<sub>2</sub>@p-rGO, used in a clean sustainable manner for rapid electrochemical determination of an anti-diabetic agent, repaglinide (RPG). Three-dimensional porous reduced graphen...
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MDPI AG
2023-01-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/11/1/50 |
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| author | Ayyapayya Mathad Karuna Korgaonkar Seetharamappa Jaldappagari Shankara Kalanur |
| author_facet | Ayyapayya Mathad Karuna Korgaonkar Seetharamappa Jaldappagari Shankara Kalanur |
| author_sort | Ayyapayya Mathad |
| collection | DOAJ |
| description | Herein, we have reported on a simple, environmentally friendly, and ultra-sensitive electrode material, SnO<sub>2</sub>@p-rGO, used in a clean sustainable manner for rapid electrochemical determination of an anti-diabetic agent, repaglinide (RPG). Three-dimensional porous reduced graphene oxide nanostructure (p-rGO) was prepared via a low-temperature solution combustion method employing glycine. The aqueous extract of agricultural waste “cotton boll peel” served as stabilizing and reducing agents for the synthesis of SnO<sub>2</sub> nanoparticles. The structural and morphological characterization was carried out by XRD, Raman, SEM, EDX, FTIR, absorption, and TGA. The oxidation process of RPG was realized under adsorption controlled with the involvement of two protons and electrons. The sensor displayed a wider linearity between the concentration of RPG and oxidation peak current in the ranges of 1.99 × 10<sup>−8</sup>–1.45 × 10<sup>−5</sup> M and 4.99 × 10<sup>−8</sup>–1.83 × 10<sup>−5</sup> M for square-wave voltammetric and differential pulse voltammetric methods, respectively. The lower limit of detection value of 0.85 × 10<sup>−9</sup> M was realized with the SWV method. The proposed sensor was applied for the quantification of RPG in fortified urine samples and pharmaceutical formulations. Furthermore, the sensor demonstrated reproducibility, long-term stability, and selectivity in the presence of metformin and other interferents, which made the proposed sensor promising and superior for monitoring RPG. |
| first_indexed | 2024-03-09T13:10:46Z |
| format | Article |
| id | doaj.art-97f351dd0060489f9b9296bc7a9b421c |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-09T13:10:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-97f351dd0060489f9b9296bc7a9b421c2023-11-30T21:41:54ZengMDPI AGChemosensors2227-90402023-01-011115010.3390/chemosensors11010050Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, RepaglinideAyyapayya Mathad0Karuna Korgaonkar1Seetharamappa Jaldappagari2Shankara Kalanur3Department of Chemistry, Karnatak University, Dharwad 580003, IndiaDepartment of Chemistry, Karnatak University, Dharwad 580003, IndiaDepartment of Chemistry, Karnatak University, Dharwad 580003, IndiaHydrogen Research Institute (IRH), Université du Québec à Trois-Rivière, 3351 Boulevard des Forges, Trois-Rivières, QC G9A 5H7, CanadaHerein, we have reported on a simple, environmentally friendly, and ultra-sensitive electrode material, SnO<sub>2</sub>@p-rGO, used in a clean sustainable manner for rapid electrochemical determination of an anti-diabetic agent, repaglinide (RPG). Three-dimensional porous reduced graphene oxide nanostructure (p-rGO) was prepared via a low-temperature solution combustion method employing glycine. The aqueous extract of agricultural waste “cotton boll peel” served as stabilizing and reducing agents for the synthesis of SnO<sub>2</sub> nanoparticles. The structural and morphological characterization was carried out by XRD, Raman, SEM, EDX, FTIR, absorption, and TGA. The oxidation process of RPG was realized under adsorption controlled with the involvement of two protons and electrons. The sensor displayed a wider linearity between the concentration of RPG and oxidation peak current in the ranges of 1.99 × 10<sup>−8</sup>–1.45 × 10<sup>−5</sup> M and 4.99 × 10<sup>−8</sup>–1.83 × 10<sup>−5</sup> M for square-wave voltammetric and differential pulse voltammetric methods, respectively. The lower limit of detection value of 0.85 × 10<sup>−9</sup> M was realized with the SWV method. The proposed sensor was applied for the quantification of RPG in fortified urine samples and pharmaceutical formulations. Furthermore, the sensor demonstrated reproducibility, long-term stability, and selectivity in the presence of metformin and other interferents, which made the proposed sensor promising and superior for monitoring RPG.https://www.mdpi.com/2227-9040/11/1/50Porous reduced graphene oxideSnO<sub>2</sub> nanoparticlessensorrepaglinide |
| spellingShingle | Ayyapayya Mathad Karuna Korgaonkar Seetharamappa Jaldappagari Shankara Kalanur Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide Chemosensors Porous reduced graphene oxide SnO<sub>2</sub> nanoparticles sensor repaglinide |
| title | Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide |
| title_full | Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide |
| title_fullStr | Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide |
| title_full_unstemmed | Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide |
| title_short | Ultrasensitive Electrochemical Sensor Based on SnO<sub>2</sub> Anchored 3D Porous Reduced Graphene Oxide Nanostructure Produced via Sustainable Green Protocol for Subnanomolar Determination of Anti-Diabetic Drug, Repaglinide |
| title_sort | ultrasensitive electrochemical sensor based on sno sub 2 sub anchored 3d porous reduced graphene oxide nanostructure produced via sustainable green protocol for subnanomolar determination of anti diabetic drug repaglinide |
| topic | Porous reduced graphene oxide SnO<sub>2</sub> nanoparticles sensor repaglinide |
| url | https://www.mdpi.com/2227-9040/11/1/50 |
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