Biomarkers of sickle cell nephropathy in Senegal
Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This c...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/?tool=EBI |
| _version_ | 1811211420477423616 |
|---|---|
| author | El Hadji Malick Ndour Khuthala Mnika Fatou Guèye Tall Moussa Seck Indou Dème Ly Victoria Nembaware Gaston Kuzamunu Mazandu Hélène Ange Thérèse Sagna Bassène Rokhaya Dione Aliou Abdoulaye Ndongo Jean Pascal Demba Diop Nènè Oumou Kesso Barry Moustapha Djité Rokhaya Ndiaye Diallo Papa Madièye Guèye Saliou Diop Ibrahima Diagne Aynina Cissé Ambroise Wonkam Philomène Lopez Sall |
| author_facet | El Hadji Malick Ndour Khuthala Mnika Fatou Guèye Tall Moussa Seck Indou Dème Ly Victoria Nembaware Gaston Kuzamunu Mazandu Hélène Ange Thérèse Sagna Bassène Rokhaya Dione Aliou Abdoulaye Ndongo Jean Pascal Demba Diop Nènè Oumou Kesso Barry Moustapha Djité Rokhaya Ndiaye Diallo Papa Madièye Guèye Saliou Diop Ibrahima Diagne Aynina Cissé Ambroise Wonkam Philomène Lopez Sall |
| author_sort | El Hadji Malick Ndour |
| collection | DOAJ |
| description | Sickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA. |
| first_indexed | 2024-04-12T05:12:43Z |
| format | Article |
| id | doaj.art-97f4c5efb8e842458e417b78f5558cc4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T05:12:43Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-97f4c5efb8e842458e417b78f5558cc42022-12-22T03:46:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711Biomarkers of sickle cell nephropathy in SenegalEl Hadji Malick NdourKhuthala MnikaFatou Guèye TallMoussa SeckIndou Dème LyVictoria NembawareGaston Kuzamunu MazanduHélène Ange Thérèse Sagna BassèneRokhaya DioneAliou Abdoulaye NdongoJean Pascal Demba DiopNènè Oumou Kesso BarryMoustapha DjitéRokhaya Ndiaye DialloPapa Madièye GuèyeSaliou DiopIbrahima DiagneAynina CisséAmbroise WonkamPhilomène Lopez SallSickle cell anemia (SCA) is caused by a single point variation in the β-globin gene (HBB): c.20A> T (p.Glu7Val), in homozygous state. SCA is characterized by sickling of red blood cells in small blood vessels which leads to a range of multiorgan complications, including kidney dysfunction. This case-control study aims at identifying sickle cell nephropathy biomarkers in a group of patients living with SCA from Senegal. A total of 163 patients living with SCA and 177 ethnic matched controls were investigated. Biological phenotyping included evaluation of glycemia, glucosuria, albuminuria, proteinuria, tubular proteinuria, serum creatinine, urine creatinine, urine specific gravity and glomerular filtration rate. Descriptive statistics of biomarkers were performed using the χ2 –test, with the significance level set at p<0.05. Patients living with SCA had a median age of 20 years (range 4 to 57) with a female sex frequency of 53.21%. The median age of the control participants was 29 years (range: 4–77) with a female sex frequency of 66.09%. The following proportions of abnormal biological indices were observed in SCA patients versus (vs.) controls, as follows: hyposthenuria: 35.3%vs.5.2% (p<0.001); glomerular hyperfiltration: 47.66%vs.19.75% (p<0.001), renal insufficiency: 5.47%vs.3.82% (p = 0.182); microalbuminuria: 42.38%vs.5.78% (p<0.001); proteinuria: 39.33%vs.4.62% (p<0.001); tubular proteinuria: 40.97%vs.4.73% (p<0.001) and microglucosuria: 22.5%vs.5.1% (p<0.001). This study shows a relatively high proportion of SCA nephropathy among patients living with SCA in Senegal. Microglucosuria, proteinuria, tubular proteinuria, microalbuminuria, hyposthenuria and glomerular hyperfiltration are the most prevalent biomarkers of nephropathy in this group of Senegalese patients with SCA.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/?tool=EBI |
| spellingShingle | El Hadji Malick Ndour Khuthala Mnika Fatou Guèye Tall Moussa Seck Indou Dème Ly Victoria Nembaware Gaston Kuzamunu Mazandu Hélène Ange Thérèse Sagna Bassène Rokhaya Dione Aliou Abdoulaye Ndongo Jean Pascal Demba Diop Nènè Oumou Kesso Barry Moustapha Djité Rokhaya Ndiaye Diallo Papa Madièye Guèye Saliou Diop Ibrahima Diagne Aynina Cissé Ambroise Wonkam Philomène Lopez Sall Biomarkers of sickle cell nephropathy in Senegal PLoS ONE |
| title | Biomarkers of sickle cell nephropathy in Senegal |
| title_full | Biomarkers of sickle cell nephropathy in Senegal |
| title_fullStr | Biomarkers of sickle cell nephropathy in Senegal |
| title_full_unstemmed | Biomarkers of sickle cell nephropathy in Senegal |
| title_short | Biomarkers of sickle cell nephropathy in Senegal |
| title_sort | biomarkers of sickle cell nephropathy in senegal |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678278/?tool=EBI |
| work_keys_str_mv | AT elhadjimalickndour biomarkersofsicklecellnephropathyinsenegal AT khuthalamnika biomarkersofsicklecellnephropathyinsenegal AT fatougueyetall biomarkersofsicklecellnephropathyinsenegal AT moussaseck biomarkersofsicklecellnephropathyinsenegal AT indoudemely biomarkersofsicklecellnephropathyinsenegal AT victorianembaware biomarkersofsicklecellnephropathyinsenegal AT gastonkuzamunumazandu biomarkersofsicklecellnephropathyinsenegal AT heleneangetheresesagnabassene biomarkersofsicklecellnephropathyinsenegal AT rokhayadione biomarkersofsicklecellnephropathyinsenegal AT aliouabdoulayendongo biomarkersofsicklecellnephropathyinsenegal AT jeanpascaldembadiop biomarkersofsicklecellnephropathyinsenegal AT neneoumoukessobarry biomarkersofsicklecellnephropathyinsenegal AT moustaphadjite biomarkersofsicklecellnephropathyinsenegal AT rokhayandiayediallo biomarkersofsicklecellnephropathyinsenegal AT papamadieyegueye biomarkersofsicklecellnephropathyinsenegal AT salioudiop biomarkersofsicklecellnephropathyinsenegal AT ibrahimadiagne biomarkersofsicklecellnephropathyinsenegal AT ayninacisse biomarkersofsicklecellnephropathyinsenegal AT ambroisewonkam biomarkersofsicklecellnephropathyinsenegal AT philomenelopezsall biomarkersofsicklecellnephropathyinsenegal |