Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty
Central precocious puberty (CPP) is defined as the appearance of secondary sexual signs in girls younger than eight years of age or the onset of menarche before the age of 10 years. Gonadotropin-releasing hormone analogs (GnRHa) are the most effective therapy in CPP. Drug-induced hypersensitivity va...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2023-09-01
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| Series: | JCRPE |
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| Online Access: | https://jcrpe.org/jvi.aspx?pdir=jcrpe&plng=eng&un=JCRPE-32032&look4= |
| _version_ | 1797737592520704000 |
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| author | Nilüfer Galip Nermin Ankay Rüveyde Bundak |
| author_facet | Nilüfer Galip Nermin Ankay Rüveyde Bundak |
| author_sort | Nilüfer Galip |
| collection | DOAJ |
| description | Central precocious puberty (CPP) is defined as the appearance of secondary sexual signs in girls younger than eight years of age or the onset of menarche before the age of 10 years. Gonadotropin-releasing hormone analogs (GnRHa) are the most effective therapy in CPP. Drug-induced hypersensitivity vasculitis is an inflammation of blood vessels, which may be due to the use of a number of pharmacologic agents. This case report describes drug-induced vasculitis in a girl being treated with Decapeptyl. A 7.25 year-old girl was admitted to Pediatric Endocrinology outpatients with premature breast development. She was diagnosed with CPP on the basis of physical examination and laboratory findings and tripoteline acetate (Decapeptyl®) treatment was initiated. She experienced multiple widespread skin rashes and mild abdominal pain with high temperature eight hours after the second dose of Decapeptyl. She was admitted to hospital with the diagnosis of drug-induced vasculitis and a single dose of intravenous methyl-prednisolone (1 mg/kg) and oral cetirizine was given. Her blood and urine analysis revealed no other organ involvement, other than skin. On the third day, the purpuric lesions began to resolve and had completely disappeared by the sixth day. Her treatment for CPP was switched to Depot Leuprolide acetate and she continued her treatment for two years uneventfully. To the best of our knowledge, this is the first report of a child with CPP experiencing drug-induced vasculitis due to tripotelin injection. Effective treatment may be continued by switching to an alternative gonadotropin releasing hormone analog. |
| first_indexed | 2024-03-12T13:31:37Z |
| format | Article |
| id | doaj.art-97f4d75d103c49c3b084eae2ae027099 |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-03-12T13:31:37Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-97f4d75d103c49c3b084eae2ae0270992023-08-24T11:28:46ZengGalenos YayincilikJCRPE1308-57271308-57352023-09-0115330731110.4274/jcrpe.galenos.2021.2021.0205JCRPE-32032Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious PubertyNilüfer Galip0https://orcid.org/0000-0002-6982-2083Nermin Ankay1https://orcid.org/0000-0003-4642-221XRüveyde Bundak2https://orcid.org/0000-0001-5097-6448University of Kyrenia, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Clinical Immunology, Kyrenia, North CyprusDr. Burhan Nalbantoğlu State Hospital, Clinic of Pediatrics, Nicosia, North CyprusUniversity of Kyrenia, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Kyrenia, North CyprusCentral precocious puberty (CPP) is defined as the appearance of secondary sexual signs in girls younger than eight years of age or the onset of menarche before the age of 10 years. Gonadotropin-releasing hormone analogs (GnRHa) are the most effective therapy in CPP. Drug-induced hypersensitivity vasculitis is an inflammation of blood vessels, which may be due to the use of a number of pharmacologic agents. This case report describes drug-induced vasculitis in a girl being treated with Decapeptyl. A 7.25 year-old girl was admitted to Pediatric Endocrinology outpatients with premature breast development. She was diagnosed with CPP on the basis of physical examination and laboratory findings and tripoteline acetate (Decapeptyl®) treatment was initiated. She experienced multiple widespread skin rashes and mild abdominal pain with high temperature eight hours after the second dose of Decapeptyl. She was admitted to hospital with the diagnosis of drug-induced vasculitis and a single dose of intravenous methyl-prednisolone (1 mg/kg) and oral cetirizine was given. Her blood and urine analysis revealed no other organ involvement, other than skin. On the third day, the purpuric lesions began to resolve and had completely disappeared by the sixth day. Her treatment for CPP was switched to Depot Leuprolide acetate and she continued her treatment for two years uneventfully. To the best of our knowledge, this is the first report of a child with CPP experiencing drug-induced vasculitis due to tripotelin injection. Effective treatment may be continued by switching to an alternative gonadotropin releasing hormone analog.https://jcrpe.org/jvi.aspx?pdir=jcrpe&plng=eng&un=JCRPE-32032&look4=drug-inducedcentral precocious pubertyvasculitisvasculitis-like rash |
| spellingShingle | Nilüfer Galip Nermin Ankay Rüveyde Bundak Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty JCRPE drug-induced central precocious puberty vasculitis vasculitis-like rash |
| title | Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty |
| title_full | Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty |
| title_fullStr | Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty |
| title_full_unstemmed | Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty |
| title_short | Vasculitis-like Palpable Purpuric Rash Induced by Decapeptyl in a Pediatric Patient Diagnosed Central Precocious Puberty |
| title_sort | vasculitis like palpable purpuric rash induced by decapeptyl in a pediatric patient diagnosed central precocious puberty |
| topic | drug-induced central precocious puberty vasculitis vasculitis-like rash |
| url | https://jcrpe.org/jvi.aspx?pdir=jcrpe&plng=eng&un=JCRPE-32032&look4= |
| work_keys_str_mv | AT nilufergalip vasculitislikepalpablepurpuricrashinducedbydecapeptylinapediatricpatientdiagnosedcentralprecociouspuberty AT nerminankay vasculitislikepalpablepurpuricrashinducedbydecapeptylinapediatricpatientdiagnosedcentralprecociouspuberty AT ruveydebundak vasculitislikepalpablepurpuricrashinducedbydecapeptylinapediatricpatientdiagnosedcentralprecociouspuberty |