An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis
Summary Polyhydroxyalkanoates (PHA) are a promising and sustainable alternative to the petroleum‐based synthetic plastics. Regulation of PHA synthesis is receiving considerable importance as engineering the regulatory factors might help developing strains with improved PHA‐producing abilities. PHA s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-05-01
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| Series: | Microbial Biotechnology |
| Online Access: | https://doi.org/10.1111/1751-7915.13915 |
| _version_ | 1818009466148225024 |
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| author | Ruchira Mitra Tong Xu Guo‐Qiang Chen Hua Xiang Jing Han |
| author_facet | Ruchira Mitra Tong Xu Guo‐Qiang Chen Hua Xiang Jing Han |
| author_sort | Ruchira Mitra |
| collection | DOAJ |
| description | Summary Polyhydroxyalkanoates (PHA) are a promising and sustainable alternative to the petroleum‐based synthetic plastics. Regulation of PHA synthesis is receiving considerable importance as engineering the regulatory factors might help developing strains with improved PHA‐producing abilities. PHA synthesis is dedicatedly regulated by a number of regulatory networks. They tightly control the PHA content, granule size and their distribution in cells. Most PHA‐accumulating microorganisms have multiple regulatory networks that impart a combined effect on PHA metabolism. Among them, several factors ranging from global to specific regulators, have been identified and characterized till now. This review is an attempt to categorically summarize the diverse regulatory circuits that operate in some important PHA‐producing microorganisms. However, in several organisms, the detailed mechanisms involved in the regulation of PHA synthesis is not well‐explored and hence further research is needed. The information presented in this review might help researcher to identify the prevailing research gaps in PHA regulation. |
| first_indexed | 2024-04-14T05:43:12Z |
| format | Article |
| id | doaj.art-97f5f241a0a84234afbadcf7e462aa59 |
| institution | Directory Open Access Journal |
| issn | 1751-7915 |
| language | English |
| last_indexed | 2024-04-14T05:43:12Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj.art-97f5f241a0a84234afbadcf7e462aa592022-12-22T02:09:23ZengWileyMicrobial Biotechnology1751-79152022-05-011551446147010.1111/1751-7915.13915An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesisRuchira Mitra0Tong Xu1Guo‐Qiang Chen2Hua Xiang3Jing Han4State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 ChinaState Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 ChinaCenter for Synthetic and Systems Biology School of Life Sciences Tsinghua University Beijing ChinaState Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 ChinaState Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 ChinaSummary Polyhydroxyalkanoates (PHA) are a promising and sustainable alternative to the petroleum‐based synthetic plastics. Regulation of PHA synthesis is receiving considerable importance as engineering the regulatory factors might help developing strains with improved PHA‐producing abilities. PHA synthesis is dedicatedly regulated by a number of regulatory networks. They tightly control the PHA content, granule size and their distribution in cells. Most PHA‐accumulating microorganisms have multiple regulatory networks that impart a combined effect on PHA metabolism. Among them, several factors ranging from global to specific regulators, have been identified and characterized till now. This review is an attempt to categorically summarize the diverse regulatory circuits that operate in some important PHA‐producing microorganisms. However, in several organisms, the detailed mechanisms involved in the regulation of PHA synthesis is not well‐explored and hence further research is needed. The information presented in this review might help researcher to identify the prevailing research gaps in PHA regulation.https://doi.org/10.1111/1751-7915.13915 |
| spellingShingle | Ruchira Mitra Tong Xu Guo‐Qiang Chen Hua Xiang Jing Han An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis Microbial Biotechnology |
| title | An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis |
| title_full | An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis |
| title_fullStr | An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis |
| title_full_unstemmed | An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis |
| title_short | An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis |
| title_sort | updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis |
| url | https://doi.org/10.1111/1751-7915.13915 |
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