Efflux Pump (QacA, QacB, and QacC) and β-Lactamase Inhibitors? An Evaluation of 1,8-Naphthyridines against <i>Staphylococcus aureus</i> Strains

Efflux Pump (QacA, QacB, and QacC) and β-Lactamase Inhibitors? An Evaluation of 1,8-Naphthyridines against <i>Staphylococcus aureus</i> Strains

The bacterial species <i>Staphylococcus aureus</i> presents a variety of resistance mechanisms, among which the expression of β-lactamases and efflux pumps stand out for providing a significant degree of resistance to clinically relevant antibiotics. The 1,8-naphthyridines are nitrogen h...

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Bibliographic Details
Main Authors: Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Ana Carolina Justino de Araújo, Cristina Rodrigues dos Santos Barbosa, Priscilla Ramos Freitas, José Bezerra de Araújo Neto, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Humberto Medeiros Barreto, Jaime Ribeiro-Filho, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
1,8-naphthyridines
bacterial resistance
β-lactamase
QacA/B efflux pumps
<i>S. aureus</i>
Online Access:https://www.mdpi.com/1420-3049/28/4/1819

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