The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone
Glioma-associated oncogene homolog 1 (Gli1) is a transcriptional activator of hedgehog (Hh) signaling that regulates target gene expression and several cellular biological processes. Cell lineage tracing techniques have highlighted Gli1 as an ideal marker for mesenchymal stem cells (MSCs) in vivo. G...
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MDPI AG
2023-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/9/1351 |
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| author | Laidi Wu Zhixin Liu Li Xiao Mi Ai Yingguang Cao Jing Mao Ke Song |
| author_facet | Laidi Wu Zhixin Liu Li Xiao Mi Ai Yingguang Cao Jing Mao Ke Song |
| author_sort | Laidi Wu |
| collection | DOAJ |
| description | Glioma-associated oncogene homolog 1 (Gli1) is a transcriptional activator of hedgehog (Hh) signaling that regulates target gene expression and several cellular biological processes. Cell lineage tracing techniques have highlighted Gli1 as an ideal marker for mesenchymal stem cells (MSCs) in vivo. Gli1<sup>+</sup> MSCs are critical for the osteogenesis of the craniofacial bone; however, the regulatory mechanism by which Gli1<sup>+</sup> MSCs mediate the bone development and tissue regeneration of craniofacial bone has not been systematically outlined. This review comprehensively elucidates the specific roles of Gli1<sup>+</sup> MSCs in craniofacial bone osteogenesis. In addition to governing craniofacial bone development, Gli1<sup>+</sup> MSCs are associated with the tissue repair of craniofacial bone under pathological conditions. Gli1<sup>+</sup> MSCs promote intramembranous and endochondral ossification of the craniofacial bones, and assist the osteogenesis of the craniofacial bone by improving angiopoiesis. This review summarizes the novel role of Gli1<sup>+</sup> MSCs in bone development and tissue repair in craniofacial bones, which offers new insights into bone regeneration therapy. |
| first_indexed | 2024-03-10T22:59:31Z |
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| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T22:59:31Z |
| publishDate | 2023-09-01 |
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| series | Biomolecules |
| spelling | doaj.art-97f835b2ef9b44be81520f09d20a165a2023-11-19T09:45:45ZengMDPI AGBiomolecules2218-273X2023-09-01139135110.3390/biom13091351The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial BoneLaidi Wu0Zhixin Liu1Li Xiao2Mi Ai3Yingguang Cao4Jing Mao5Ke Song6Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaGlioma-associated oncogene homolog 1 (Gli1) is a transcriptional activator of hedgehog (Hh) signaling that regulates target gene expression and several cellular biological processes. Cell lineage tracing techniques have highlighted Gli1 as an ideal marker for mesenchymal stem cells (MSCs) in vivo. Gli1<sup>+</sup> MSCs are critical for the osteogenesis of the craniofacial bone; however, the regulatory mechanism by which Gli1<sup>+</sup> MSCs mediate the bone development and tissue regeneration of craniofacial bone has not been systematically outlined. This review comprehensively elucidates the specific roles of Gli1<sup>+</sup> MSCs in craniofacial bone osteogenesis. In addition to governing craniofacial bone development, Gli1<sup>+</sup> MSCs are associated with the tissue repair of craniofacial bone under pathological conditions. Gli1<sup>+</sup> MSCs promote intramembranous and endochondral ossification of the craniofacial bones, and assist the osteogenesis of the craniofacial bone by improving angiopoiesis. This review summarizes the novel role of Gli1<sup>+</sup> MSCs in bone development and tissue repair in craniofacial bones, which offers new insights into bone regeneration therapy.https://www.mdpi.com/2218-273X/13/9/1351Gli1mesenchymal stem cellsosteogenesiscraniofacial bone |
| spellingShingle | Laidi Wu Zhixin Liu Li Xiao Mi Ai Yingguang Cao Jing Mao Ke Song The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone Biomolecules Gli1 mesenchymal stem cells osteogenesis craniofacial bone |
| title | The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone |
| title_full | The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone |
| title_fullStr | The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone |
| title_full_unstemmed | The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone |
| title_short | The Role of Gli1<sup>+</sup> Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone |
| title_sort | role of gli1 sup sup mesenchymal stem cells in osteogenesis of craniofacial bone |
| topic | Gli1 mesenchymal stem cells osteogenesis craniofacial bone |
| url | https://www.mdpi.com/2218-273X/13/9/1351 |
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