Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders

Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders

The ryanodine receptor (RyR) is a homotetrameric channel mediating sarcoplasmic reticulum Ca2+ release required for skeletal and cardiac muscle contraction. Mutations in RyR1 and RyR2 lead to life-threatening malignant hyperthermia episodes and ventricular tachycardia, respectively. In this brief re...

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Bibliographic Details
Main Authors: Yadan Zhang, Camille Rabesahala de Meritens, Astrid Beckmann, F. Anthony Lai, Spyros Zissimopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Physiology
Subjects:
amino-terminus
catecholaminergic polymorphic ventricular tachycardia
malignant hyperthermia
inter-subunit interaction
tetramerization
ryanodine receptor (RyR)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1032132/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.1032132/full

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