Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging
We describe by NG2 (neuron-glia chondroitin sulphate proteoglycan 2) immunocytochemistry an uneven distribution of NG2 glial cells in the rat cerebellum, being them more represented in the central lobules of the cerebellar vermis, belonging to the cerebrocerebellum. The cerebellar distribution of NG...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-06-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | http://www.ejh.it/index.php/ejh/article/view/2023 |
| _version_ | 1818532039310180352 |
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| author | S. Lomoio D. Necchi E. Scherini |
| author_facet | S. Lomoio D. Necchi E. Scherini |
| author_sort | S. Lomoio |
| collection | DOAJ |
| description | We describe by NG2 (neuron-glia chondroitin sulphate proteoglycan 2) immunocytochemistry an uneven distribution of NG2 glial cells in the rat cerebellum, being them more represented in the central lobules of the cerebellar vermis, belonging to the cerebrocerebellum. The cerebellar distribution of NG2 cells changes in aging rats, in which the area where the cells appear to be densely scattered throughout all cerebellar layers involves also more rostral and caudal lobules. In addition, in aging rats, in the most rostral and caudal lobules belonging to the spinocerebellum, punctate reaction product is present at the apical pole of Purkinje cells, i.e. in the area where the majority of synapses between olivary climbing fibers and Purkinje cells occur. Data suggest that the different distribution of NG2 cells is correlated to differences in physiology among cerebellar areas and reflects changes during aging. |
| first_indexed | 2024-12-11T17:40:19Z |
| format | Article |
| id | doaj.art-97fd0a37d7d8483382640e03f10c50c8 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-11T17:40:19Z |
| publishDate | 2012-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-97fd0a37d7d8483382640e03f10c50c82022-12-22T00:56:33ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062012-06-01563e27e2710.4081/ejh.2012.e271278Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in agingS. Lomoio0D. Necchi1E. Scherini2Dipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”, Università di Pavia, via Ferrata 9, 27100 Pavia, ItalyDipartimento di Scienze del Farmaco, Università di Pavia, via Taramelli 14, 27100 Pavia, ItalyDipartimento di Biologia e Biotecnologie “Lazzaro Spallanzani”, Università di Pavia, via Ferrata 9, 27100 Pavia, ItalyWe describe by NG2 (neuron-glia chondroitin sulphate proteoglycan 2) immunocytochemistry an uneven distribution of NG2 glial cells in the rat cerebellum, being them more represented in the central lobules of the cerebellar vermis, belonging to the cerebrocerebellum. The cerebellar distribution of NG2 cells changes in aging rats, in which the area where the cells appear to be densely scattered throughout all cerebellar layers involves also more rostral and caudal lobules. In addition, in aging rats, in the most rostral and caudal lobules belonging to the spinocerebellum, punctate reaction product is present at the apical pole of Purkinje cells, i.e. in the area where the majority of synapses between olivary climbing fibers and Purkinje cells occur. Data suggest that the different distribution of NG2 cells is correlated to differences in physiology among cerebellar areas and reflects changes during aging.http://www.ejh.it/index.php/ejh/article/view/2023cerebellum, aging, NG2 glia |
| spellingShingle | S. Lomoio D. Necchi E. Scherini Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging European Journal of Histochemistry cerebellum, aging, NG2 glia |
| title | Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging |
| title_full | Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging |
| title_fullStr | Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging |
| title_full_unstemmed | Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging |
| title_short | Uneven distribution of NG2 cells in the rat cerebellar vermis and changes in aging |
| title_sort | uneven distribution of ng2 cells in the rat cerebellar vermis and changes in aging |
| topic | cerebellum, aging, NG2 glia |
| url | http://www.ejh.it/index.php/ejh/article/view/2023 |
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