One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan
Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased rapidly in recent decades, with a favorable overall prognosis. We aimed to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating low-risk PTMC in Taiwan. Methods: This p...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664621004721 |
| _version_ | 1818048762975617024 |
|---|---|
| author | Lay San Lim Wei-Che Lin Pi-Ling Chiang Shun Chen Huang Yueh-Sheng Chen Yen-Hsiang Chang Wen-Chieh Chen Shun-Yu Chi Chen-Kai Chou |
| author_facet | Lay San Lim Wei-Che Lin Pi-Ling Chiang Shun Chen Huang Yueh-Sheng Chen Yen-Hsiang Chang Wen-Chieh Chen Shun-Yu Chi Chen-Kai Chou |
| author_sort | Lay San Lim |
| collection | DOAJ |
| description | Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased rapidly in recent decades, with a favorable overall prognosis. We aimed to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating low-risk PTMC in Taiwan. Methods: This prospective study included patients with PTMC who were ineligible or refused surgery and underwent US-guided RFA between October 2018 and June 2020. US and computed tomography (CT) were performed before RFA to assess tumor lesions and exclude cervical lymph node metastasis. Sequential US follow-up following RFA was performed after 1, 3, 6, and 12 months, and yearly thereafter. Volume reduction ratio (VRR) and complete disappearance rate of tumor at one year were evaluated. Results: 13 PTMCs in 12 patients were enrolled with a mean follow-up of 16.2 ± 8.1 months (range, 1–24 months). The median largest tumor diameter and tumor volume before RFA were 0.76 cm and 0.15 ml (range, 0.02–0.37 ml). The median (interquartile range, IQR) volume and VRR at 12 months post-RFA were 0 (0, 0.03) ml (p = 0.033) and 100% (84.26%, 100%) (p = 0.008). Eight tumors (61.54%) were completely disappeared at 12 months post-RFA and no tumor recurrence, lymph nodes, or distant metastasis were noted. All tumors were successfully treated without complications. Conclusion: Minimally invasive US-guided RFA is an effective and safe alternative for low-risk PTMC, resulting a satisfied VRR. |
| first_indexed | 2024-12-10T10:26:51Z |
| format | Article |
| id | doaj.art-97fd68201e3949c0821bfa71eb99fd8e |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-10T10:26:51Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-97fd68201e3949c0821bfa71eb99fd8e2022-12-22T01:52:41ZengElsevierJournal of the Formosan Medical Association0929-66462022-08-01121814061413One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in TaiwanLay San Lim0Wei-Che Lin1Pi-Ling Chiang2Shun Chen Huang3Yueh-Sheng Chen4Yen-Hsiang Chang5Wen-Chieh Chen6Shun-Yu Chi7Chen-Kai Chou8Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Corresponding author. Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung, Taiwan. Fax: +886 7 731 7123 EXT 2523.Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartments of Pathology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartments of Surgery, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Corresponding author. Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung, Kaohsiung, Taiwan. Fax: + 886 7 732 2402.Background: The incidence of papillary thyroid microcarcinoma (PTMC) has increased rapidly in recent decades, with a favorable overall prognosis. We aimed to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating low-risk PTMC in Taiwan. Methods: This prospective study included patients with PTMC who were ineligible or refused surgery and underwent US-guided RFA between October 2018 and June 2020. US and computed tomography (CT) were performed before RFA to assess tumor lesions and exclude cervical lymph node metastasis. Sequential US follow-up following RFA was performed after 1, 3, 6, and 12 months, and yearly thereafter. Volume reduction ratio (VRR) and complete disappearance rate of tumor at one year were evaluated. Results: 13 PTMCs in 12 patients were enrolled with a mean follow-up of 16.2 ± 8.1 months (range, 1–24 months). The median largest tumor diameter and tumor volume before RFA were 0.76 cm and 0.15 ml (range, 0.02–0.37 ml). The median (interquartile range, IQR) volume and VRR at 12 months post-RFA were 0 (0, 0.03) ml (p = 0.033) and 100% (84.26%, 100%) (p = 0.008). Eight tumors (61.54%) were completely disappeared at 12 months post-RFA and no tumor recurrence, lymph nodes, or distant metastasis were noted. All tumors were successfully treated without complications. Conclusion: Minimally invasive US-guided RFA is an effective and safe alternative for low-risk PTMC, resulting a satisfied VRR.http://www.sciencedirect.com/science/article/pii/S0929664621004721Papillary thyroid microcarcinomaRadiofrequency ablationUltrasound |
| spellingShingle | Lay San Lim Wei-Che Lin Pi-Ling Chiang Shun Chen Huang Yueh-Sheng Chen Yen-Hsiang Chang Wen-Chieh Chen Shun-Yu Chi Chen-Kai Chou One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan Journal of the Formosan Medical Association Papillary thyroid microcarcinoma Radiofrequency ablation Ultrasound |
| title | One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan |
| title_full | One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan |
| title_fullStr | One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan |
| title_full_unstemmed | One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan |
| title_short | One year follow-up of US-Guided radiofrequency ablation for low-risk papillary thyroid microcarcinoma: The first experience in Taiwan |
| title_sort | one year follow up of us guided radiofrequency ablation for low risk papillary thyroid microcarcinoma the first experience in taiwan |
| topic | Papillary thyroid microcarcinoma Radiofrequency ablation Ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S0929664621004721 |
| work_keys_str_mv | AT laysanlim oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT weichelin oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT pilingchiang oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT shunchenhuang oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT yuehshengchen oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT yenhsiangchang oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT wenchiehchen oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT shunyuchi oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan AT chenkaichou oneyearfollowupofusguidedradiofrequencyablationforlowriskpapillarythyroidmicrocarcinomathefirstexperienceintaiwan |