GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.

Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson's disease...

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Main Authors: Anmol Kumar, Jaakko Kopra, Kärt Varendi, Lauriina L Porokuokka, Anne Panhelainen, Satu Kuure, Pepin Marshall, Nina Karalija, Mari-Anne Härma, Carolina Vilenius, Kersti Lilleväli, Triin Tekko, Jelena Mijatovic, Nita Pulkkinen, Madis Jakobson, Maili Jakobson, Roxana Ola, Erik Palm, Maria Lindahl, Ingrid Strömberg, Vootele Võikar, T Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4682981?pdf=render

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