Papillary carcinoma thyroid – A cytomorphological study
<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><strong>Background: </strong><span>Fine Needle Aspiration Cytology is a widely accepted diagnostic to...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2016-09-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | http://www.nepjol.info/index.php/JPN/article/view/16288 |
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| author | A Bhat L Varma H Fernandes CS Jayaprakash |
| author_facet | A Bhat L Varma H Fernandes CS Jayaprakash |
| author_sort | A Bhat |
| collection | DOAJ |
| description | <div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><strong>Background: </strong><span>Fine Needle Aspiration Cytology is a widely accepted diagnostic tool for thyroid lesions. It is well known that nuclear features form the mainstay of diagnosis for papillary carcinoma thyroid. Focal </span><span>nuclear features can be missed unless carefully looked for and pose diagnostic dif culty. The aim was to </span><span>study the cytomorphological features of papillary carcinoma thyroid and to calculate the percentage of nuclear grooving. </span></p><p><strong>Materials and Methods: </strong><span>This retrospective study was carried out by reviewing the data and cytology </span><span>smears of 21 histopathologically con rmed cases of papillary carcinoma thyroid. The percentage of </span><span>nuclear grooves was calculated in oil immersion by counting 200 to 500 cells depending on the cellularity. The study was approved by the institution ethical and research committee. </span></p><p><strong>Results: </strong><span>Out of the total 21 cases, 03(14.2%) were males and 18(83.8%) were females. Mean age was 38.9years. Predominant papillary arrangement was seen in 17(80.9%) of the cases. Nuclear crowding and overlapping, pale chromatin, nuclear grooves, nuclear enlargement and prominent nucleoli were seen in all (100%) the cases. Intranuclear cytoplasmic pseudoinclusions were seen in only 5(23.8%) of the cases. The percentage of nuclear grooving ranged from 15% to 85%. Greater than 20% nuclear grooves were observed in 19(90.4%) of the cases. Histiocytes, metaplastic cells and multinucleated giant cells were seen in 12(57.1%), 10(47.6%) and 6(28.5%) of the cases. </span></p><p><strong>Conclusion: </strong><span>The cytologic diagnosis of papillary carcinoma is easy when majority of the classical features are present. But it becomes really challenging when the features are either present focally or classical features are absent. </span></p></div></div></div></div> |
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| format | Article |
| id | doaj.art-97ff67697c634e21b5881604a3e28345 |
| institution | Directory Open Access Journal |
| issn | 2091-0797 2091-0908 |
| language | English |
| last_indexed | 2024-12-16T13:06:01Z |
| publishDate | 2016-09-01 |
| publisher | Association of Clinical Pathologists of Nepal |
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| series | Journal of Pathology of Nepal |
| spelling | doaj.art-97ff67697c634e21b5881604a3e283452022-12-21T22:30:45ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082016-09-016121005100710.3126/jpn.v6i12.1628812631Papillary carcinoma thyroid – A cytomorphological studyA Bhat0L Varma1H Fernandes2CS Jayaprakash3Department of pathology, Father Muller Medical College, MangaloreDepartment of pathology, Father Muller Medical College, MangaloreDepartment of pathology, Father Muller Medical College, MangaloreDepartment of pathology, Father Muller Medical College, Mangalore<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><strong>Background: </strong><span>Fine Needle Aspiration Cytology is a widely accepted diagnostic tool for thyroid lesions. It is well known that nuclear features form the mainstay of diagnosis for papillary carcinoma thyroid. Focal </span><span>nuclear features can be missed unless carefully looked for and pose diagnostic dif culty. The aim was to </span><span>study the cytomorphological features of papillary carcinoma thyroid and to calculate the percentage of nuclear grooving. </span></p><p><strong>Materials and Methods: </strong><span>This retrospective study was carried out by reviewing the data and cytology </span><span>smears of 21 histopathologically con rmed cases of papillary carcinoma thyroid. The percentage of </span><span>nuclear grooves was calculated in oil immersion by counting 200 to 500 cells depending on the cellularity. The study was approved by the institution ethical and research committee. </span></p><p><strong>Results: </strong><span>Out of the total 21 cases, 03(14.2%) were males and 18(83.8%) were females. Mean age was 38.9years. Predominant papillary arrangement was seen in 17(80.9%) of the cases. Nuclear crowding and overlapping, pale chromatin, nuclear grooves, nuclear enlargement and prominent nucleoli were seen in all (100%) the cases. Intranuclear cytoplasmic pseudoinclusions were seen in only 5(23.8%) of the cases. The percentage of nuclear grooving ranged from 15% to 85%. Greater than 20% nuclear grooves were observed in 19(90.4%) of the cases. Histiocytes, metaplastic cells and multinucleated giant cells were seen in 12(57.1%), 10(47.6%) and 6(28.5%) of the cases. </span></p><p><strong>Conclusion: </strong><span>The cytologic diagnosis of papillary carcinoma is easy when majority of the classical features are present. But it becomes really challenging when the features are either present focally or classical features are absent. </span></p></div></div></div></div>http://www.nepjol.info/index.php/JPN/article/view/16288Nuclear groovingPseudoinclusionThyroidPapillary |
| spellingShingle | A Bhat L Varma H Fernandes CS Jayaprakash Papillary carcinoma thyroid – A cytomorphological study Journal of Pathology of Nepal Nuclear grooving Pseudoinclusion Thyroid Papillary |
| title | Papillary carcinoma thyroid – A cytomorphological study |
| title_full | Papillary carcinoma thyroid – A cytomorphological study |
| title_fullStr | Papillary carcinoma thyroid – A cytomorphological study |
| title_full_unstemmed | Papillary carcinoma thyroid – A cytomorphological study |
| title_short | Papillary carcinoma thyroid – A cytomorphological study |
| title_sort | papillary carcinoma thyroid a cytomorphological study |
| topic | Nuclear grooving Pseudoinclusion Thyroid Papillary |
| url | http://www.nepjol.info/index.php/JPN/article/view/16288 |
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