PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients

PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients

OBJECTIVES: The phosphatidylinositol 3-kinase/AKT axis is an important cell-signaling pathway that mediates cell proliferation and survival, two biological processes that regulate malignant cell growth. The phosphatidylinositol 3-kinase CA gene encodes the p110α subunit of the phosphatidylinositol...

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Bibliographic Details
Main Authors: Flavia R. Mangone, Irina G. Bobrovnitchaia, Sibeli Salaorni, Erika Manuli, Maria A. Nagai
Format: Article
Language:English
Published: Elsevier España 2012-11-01
Series:Clinics
Subjects:
Breast Neoplasm
PIK3CA
TP53
Mutation
Prognosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001100011

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