Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma

Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma

Background/Purpose: Arecoline, the major alkaloid of areca nut, is known to induce reactive oxygen species (ROS) and DNA damage during oral cancer progression. This study aim to evaluate whether melatonin, an antioxidant, supported or repressed the arecoline-induced carcinogenesis phenotypes in oral...

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Bibliographic Details
Main Authors: Yin-Hwa Shih, Kuo-Chou Chiu, Tong-Hong Wang, Wan-Chen Lan, Bi-He Tsai, Li-Jia Wu, Shih-Min Hsia, Tzong-Ming Shieh
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of the Formosan Medical Association
Subjects:
Arecoline
DNA repair
Melatonin
Oral squamous cell carcinoma (OSCC)
Reactive oxygen species (ROS)
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664620303491

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