Suspected azathioprine induced liver cirrhosis: an unusual side effect
In recent years, the hepatotoxic potential of thiopurines, in particular 6-thioguanine (6-TG) has been discussed in literature. However, cirrhosis was exceptionally reported. We report the case of a 56-year-old woman with ileocaecal Crohn's disease treated with azathioprine. After taking azathi...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2014-03-01
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| Series: | The Pan African Medical Journal |
| Subjects: | |
| Online Access: |
https://www.panafrican-med-journal.com/content/article/17/174/pdf/174.pdf
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| _version_ | 1818914890809606144 |
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| author | Aida Ben Slama Trabelsi Eya Hamami Ahlem Souguir Mehdi Ksiaa Salem Ajmi Ali Jmaa |
| author_facet | Aida Ben Slama Trabelsi Eya Hamami Ahlem Souguir Mehdi Ksiaa Salem Ajmi Ali Jmaa |
| author_sort | Aida Ben Slama Trabelsi |
| collection | DOAJ |
| description | In recent years, the hepatotoxic potential of thiopurines, in particular 6-thioguanine (6-TG) has been discussed in literature. However, cirrhosis was exceptionally reported. We report the case of a 56-year-old woman with ileocaecal Crohn's disease treated with azathioprine. After taking azathioprine (2 mg/kg daily) for four years, she underwent surgical treatment for acute intestinal obstruction. In peroperative, we noticed a cirrhotic liver. A surgical biopsy was performed and the diagnosis of cirrhosis was confirmed. Autoimmune and viral liver diseases were ruled out by laboratory parameters. Therefore, Azathioprine is believed to be the causative actor for inducing liver cirrhosis. Thus, treating inflammatory bowel disease effectively while trying to limit iatrogenic disease is a continuous struggle. |
| first_indexed | 2024-12-19T23:53:35Z |
| format | Article |
| id | doaj.art-98059373f32048479352bbab1df70402 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-19T23:53:35Z |
| publishDate | 2014-03-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-98059373f32048479352bbab1df704022022-12-21T20:01:05ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882014-03-011717410.11604/pamj.2014.17.174.30183018Suspected azathioprine induced liver cirrhosis: an unusual side effectAida Ben Slama Trabelsi0Eya Hamami1Ahlem Souguir2Mehdi Ksiaa3Salem Ajmi4Ali Jmaa5 Department of Gastroenterology, Sahloul Sousse, Tunisia Department of Gastroenterology, Sahloul Sousse, Tunisia Department of Gastroenterology, Sahloul Sousse, Tunisia Department of Gastroenterology, Sahloul Sousse, Tunisia Department of Gastroenterology, Sahloul Sousse, Tunisia Department of Gastroenterology, Sahloul Sousse, Tunisia In recent years, the hepatotoxic potential of thiopurines, in particular 6-thioguanine (6-TG) has been discussed in literature. However, cirrhosis was exceptionally reported. We report the case of a 56-year-old woman with ileocaecal Crohn's disease treated with azathioprine. After taking azathioprine (2 mg/kg daily) for four years, she underwent surgical treatment for acute intestinal obstruction. In peroperative, we noticed a cirrhotic liver. A surgical biopsy was performed and the diagnosis of cirrhosis was confirmed. Autoimmune and viral liver diseases were ruled out by laboratory parameters. Therefore, Azathioprine is believed to be the causative actor for inducing liver cirrhosis. Thus, treating inflammatory bowel disease effectively while trying to limit iatrogenic disease is a continuous struggle. https://www.panafrican-med-journal.com/content/article/17/174/pdf/174.pdf azathioprinecrohn´s diseasehepatotoxicityliver cirrhosis |
| spellingShingle | Aida Ben Slama Trabelsi Eya Hamami Ahlem Souguir Mehdi Ksiaa Salem Ajmi Ali Jmaa Suspected azathioprine induced liver cirrhosis: an unusual side effect The Pan African Medical Journal azathioprine crohn´s disease hepatotoxicity liver cirrhosis |
| title | Suspected azathioprine induced liver cirrhosis: an unusual side effect |
| title_full | Suspected azathioprine induced liver cirrhosis: an unusual side effect |
| title_fullStr | Suspected azathioprine induced liver cirrhosis: an unusual side effect |
| title_full_unstemmed | Suspected azathioprine induced liver cirrhosis: an unusual side effect |
| title_short | Suspected azathioprine induced liver cirrhosis: an unusual side effect |
| title_sort | suspected azathioprine induced liver cirrhosis an unusual side effect |
| topic | azathioprine crohn´s disease hepatotoxicity liver cirrhosis |
| url |
https://www.panafrican-med-journal.com/content/article/17/174/pdf/174.pdf
|
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