Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy
Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microb...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/7/935 |
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| author | Suzanne A. Alvernaz Elizabeth S. Wenzel Unnathi Nagelli Lacey B. Pezley Bazil LaBomascus Jack A. Gilbert Pauline M. Maki Lisa Tussing-Humphreys Beatriz Peñalver Bernabé |
| author_facet | Suzanne A. Alvernaz Elizabeth S. Wenzel Unnathi Nagelli Lacey B. Pezley Bazil LaBomascus Jack A. Gilbert Pauline M. Maki Lisa Tussing-Humphreys Beatriz Peñalver Bernabé |
| author_sort | Suzanne A. Alvernaz |
| collection | DOAJ |
| description | Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored. We aimed to address this gap using a system-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Forty-seven pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from the FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundances with respect to the DII score were identified, and the microbial metabolic potential was predicted using PICRUSt2. Inflammatory diets were associated with decreased vitamin and mineral intake and a dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short-chain fatty acid producers such as <i>Faecalibacterium</i>, and an increase in predicted vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism, and multidrug efflux systems in pregnant individuals with increased DII scores. Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation. |
| first_indexed | 2024-04-24T10:38:08Z |
| format | Article |
| id | doaj.art-98068db302d542149ce9537086914729 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T10:38:08Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-98068db302d542149ce95370869147292024-04-12T13:24:09ZengMDPI AGNutrients2072-66432024-03-0116793510.3390/nu16070935Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early PregnancySuzanne A. Alvernaz0Elizabeth S. Wenzel1Unnathi Nagelli2Lacey B. Pezley3Bazil LaBomascus4Jack A. Gilbert5Pauline M. Maki6Lisa Tussing-Humphreys7Beatriz Peñalver Bernabé8Department of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USADepartment of Psychology, University of Illinois, Chicago, IL 60607, USADepartment of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USADepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USADepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USADepartment of Pediatrics, University of California, San Diego, CA 92093, USADepartment of Psychology, University of Illinois, Chicago, IL 60607, USADepartment of Kinesiology and Nutrition, University of Illinois, Chicago, IL 60612, USADepartment of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USAPregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter the host immune system to promote inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbial dysbiosis, including gestational diabetes mellitus, pre-eclampsia, preterm birth, and mood disorders. However, the effects of high-inflammatory diets on the gut microbiota during pregnancy have yet to be fully explored. We aimed to address this gap using a system-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy. Forty-seven pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from the FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxon abundances with respect to the DII score were identified, and the microbial metabolic potential was predicted using PICRUSt2. Inflammatory diets were associated with decreased vitamin and mineral intake and a dysbiotic gut microbiota structure and predicted metabolism. Gut microbial compositional differences revealed a decrease in short-chain fatty acid producers such as <i>Faecalibacterium</i>, and an increase in predicted vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism, and multidrug efflux systems in pregnant individuals with increased DII scores. Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation.https://www.mdpi.com/2072-6643/16/7/935dietinflammationpregnancygut microbiotadietary inflammatory indexgalactose |
| spellingShingle | Suzanne A. Alvernaz Elizabeth S. Wenzel Unnathi Nagelli Lacey B. Pezley Bazil LaBomascus Jack A. Gilbert Pauline M. Maki Lisa Tussing-Humphreys Beatriz Peñalver Bernabé Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy Nutrients diet inflammation pregnancy gut microbiota dietary inflammatory index galactose |
| title | Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy |
| title_full | Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy |
| title_fullStr | Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy |
| title_full_unstemmed | Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy |
| title_short | Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy |
| title_sort | inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy |
| topic | diet inflammation pregnancy gut microbiota dietary inflammatory index galactose |
| url | https://www.mdpi.com/2072-6643/16/7/935 |
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