Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate

Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate

Summary: Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend to be expressed at higher levels in human pluripote...

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Bibliographic Details
Main Authors: Chih-Hong Lou, Jennifer Dumdie, Alexandra Goetz, Eleen Y. Shum, David Brafman, Xiaoyan Liao, Sergio Mora-Castilla, Madhuvanthi Ramaiah, Heidi Cook-Andersen, Louise Laurent, Miles F. Wilkinson
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116300637

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