Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats
Johne’s disease (JD) is caused by <i>Mycobacterium avium subsp. paratuberculosis</i> (MAP) and is an important and emerging problem in livestock; therefore, its control and prevention is a priority to reduce economic losses and health risks. Most JD research has been carried out on cattl...
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MDPI AG
2021-06-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/11/7/1912 |
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| author | Palazzo Fiorentina Camillo Martino Ylenia Mancini Maria Grazia De Iorio John L. Williams Giulietta Minozzi |
| author_facet | Palazzo Fiorentina Camillo Martino Ylenia Mancini Maria Grazia De Iorio John L. Williams Giulietta Minozzi |
| author_sort | Palazzo Fiorentina |
| collection | DOAJ |
| description | Johne’s disease (JD) is caused by <i>Mycobacterium avium subsp. paratuberculosis</i> (MAP) and is an important and emerging problem in livestock; therefore, its control and prevention is a priority to reduce economic losses and health risks. Most JD research has been carried out on cattle, but interest in the pathogenesis and diagnosis of this disease in sheep and goats is greatest in developing countries. Sheep and goats are also a relevant part of livestock production in Europe and Australia, and these species provide an excellent resource to study and better understand the mechanism of survival of MAP and gain insights into possible approaches to control this disease. This review gives an overview of the literature on paratuberculosis in sheep and goats, highlighting the immunological aspects and the potential for “omics” approaches to identify effective biomarkers for the early detection of infection. As JD has a long incubation period before the disease becomes evident, early diagnosis is important to control the spread of the disease. |
| first_indexed | 2024-03-10T10:00:51Z |
| format | Article |
| id | doaj.art-980a290ee87f47019fa93dd87fcdeaa6 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T10:00:51Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-980a290ee87f47019fa93dd87fcdeaa62023-11-22T01:56:58ZengMDPI AGAnimals2076-26152021-06-01117191210.3390/ani11071912Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and GoatsPalazzo Fiorentina0Camillo Martino1Ylenia Mancini2Maria Grazia De Iorio3John L. Williams4Giulietta Minozzi5Faculty of BioScience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale” Via Campo Boario, 64100 Teramo, ItalyFaculty of BioScience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, ItalyDepartment of Veterinary Medicine DIMEVET, University of Milan, 20133 Milan, ItalySchool of Animal and Veterinary Sciences, Faculty of Sciences, University of Adelaide, Roseworthy, SA 5371, AustraliaDepartment of Veterinary Medicine DIMEVET, University of Milan, 20133 Milan, ItalyJohne’s disease (JD) is caused by <i>Mycobacterium avium subsp. paratuberculosis</i> (MAP) and is an important and emerging problem in livestock; therefore, its control and prevention is a priority to reduce economic losses and health risks. Most JD research has been carried out on cattle, but interest in the pathogenesis and diagnosis of this disease in sheep and goats is greatest in developing countries. Sheep and goats are also a relevant part of livestock production in Europe and Australia, and these species provide an excellent resource to study and better understand the mechanism of survival of MAP and gain insights into possible approaches to control this disease. This review gives an overview of the literature on paratuberculosis in sheep and goats, highlighting the immunological aspects and the potential for “omics” approaches to identify effective biomarkers for the early detection of infection. As JD has a long incubation period before the disease becomes evident, early diagnosis is important to control the spread of the disease.https://www.mdpi.com/2076-2615/11/7/1912ovinecaprineparatuberculosisimmunologydiagnostics |
| spellingShingle | Palazzo Fiorentina Camillo Martino Ylenia Mancini Maria Grazia De Iorio John L. Williams Giulietta Minozzi Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats Animals ovine caprine paratuberculosis immunology diagnostics |
| title | Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats |
| title_full | Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats |
| title_fullStr | Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats |
| title_full_unstemmed | Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats |
| title_short | Using Omics Approaches in the Discovery of Biomarkers for Early Diagnosis of Johne’s Disease in Sheep and Goats |
| title_sort | using omics approaches in the discovery of biomarkers for early diagnosis of johne s disease in sheep and goats |
| topic | ovine caprine paratuberculosis immunology diagnostics |
| url | https://www.mdpi.com/2076-2615/11/7/1912 |
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