Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma
Hepatitis B Virus (HBV) DNA integrations into the human genome are considered major causative factors to HBV-associated hepatocellular carcinoma development. In the present study, we investigated whether HBV preferentially integrates parts of its genome in specific genes and evaluated the contributi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/2/253 |
| _version_ | 1797477869626064896 |
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| author | Maria Bousali Timokratis Karamitros |
| author_facet | Maria Bousali Timokratis Karamitros |
| author_sort | Maria Bousali |
| collection | DOAJ |
| description | Hepatitis B Virus (HBV) DNA integrations into the human genome are considered major causative factors to HBV-associated hepatocellular carcinoma development. In the present study, we investigated whether HBV preferentially integrates parts of its genome in specific genes and evaluated the contribution of the integrations in HCC development per gene. We applied dedicated in-house developed pipelines on all of the available HBV DNA integration data and performed a statistical analysis to identify genes that could be characterized as hotspots of integrations, along with the evaluation of their association with HBV-HCC. Our results suggest that 15 genes are recurrently affected by HBV integrations and they are significantly associated with HBV-HCC. Further studies that focus on HBV integrations disrupting these genes are mandatory in order to understand the role of HBV integrations in clonal advantage gain and oncogenesis promotion, as well as to determine whether inhibition of the HBV-disrupted genes can provide a therapy strategy for HBV-HCC. |
| first_indexed | 2024-03-09T21:24:50Z |
| format | Article |
| id | doaj.art-980bdb9ac8094aabac721407e9b87f47 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T21:24:50Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-980bdb9ac8094aabac721407e9b87f472023-11-23T21:13:14ZengMDPI AGMicroorganisms2076-26072022-01-0110225310.3390/microorganisms10020253Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular CarcinomaMaria Bousali0Timokratis Karamitros1Bioinformatics and Applied Genomics Unit, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, GreeceBioinformatics and Applied Genomics Unit, Department of Microbiology, Hellenic Pasteur Institute, 11521 Athens, GreeceHepatitis B Virus (HBV) DNA integrations into the human genome are considered major causative factors to HBV-associated hepatocellular carcinoma development. In the present study, we investigated whether HBV preferentially integrates parts of its genome in specific genes and evaluated the contribution of the integrations in HCC development per gene. We applied dedicated in-house developed pipelines on all of the available HBV DNA integration data and performed a statistical analysis to identify genes that could be characterized as hotspots of integrations, along with the evaluation of their association with HBV-HCC. Our results suggest that 15 genes are recurrently affected by HBV integrations and they are significantly associated with HBV-HCC. Further studies that focus on HBV integrations disrupting these genes are mandatory in order to understand the role of HBV integrations in clonal advantage gain and oncogenesis promotion, as well as to determine whether inhibition of the HBV-disrupted genes can provide a therapy strategy for HBV-HCC.https://www.mdpi.com/2076-2607/10/2/253hepatitis B virusviral integrationVISpathogen–host interactionshepatocellular carcinomaHBV-HCC |
| spellingShingle | Maria Bousali Timokratis Karamitros Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma Microorganisms hepatitis B virus viral integration VIS pathogen–host interactions hepatocellular carcinoma HBV-HCC |
| title | Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma |
| title_full | Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma |
| title_fullStr | Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma |
| title_full_unstemmed | Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma |
| title_short | Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma |
| title_sort | hepatitis b virus integration into transcriptionally active loci and hbv associated hepatocellular carcinoma |
| topic | hepatitis B virus viral integration VIS pathogen–host interactions hepatocellular carcinoma HBV-HCC |
| url | https://www.mdpi.com/2076-2607/10/2/253 |
| work_keys_str_mv | AT mariabousali hepatitisbvirusintegrationintotranscriptionallyactivelociandhbvassociatedhepatocellularcarcinoma AT timokratiskaramitros hepatitisbvirusintegrationintotranscriptionallyactivelociandhbvassociatedhepatocellularcarcinoma |