Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector
BackgroundUltra-high dose rate (UHDR) radiation of electron or proton beam has been shown to spare normal tissues surrounding the tumors while killing tumor cells effectively which is called the FLASH effect (FE). However, the internal mechanisms of FE has not yet been fully revealed, and the optim...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | zho |
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Science Press
2023-11-01
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| Series: | He jishu |
| Subjects: | |
| Online Access: | http://www.hjs.sinap.ac.cn/thesisDetails#10.11889/j.0253-3219.2023.hjs.46.110201&lang=zh |
| _version_ | 1797405187871080448 |
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| author | LIU Junya YU Xiao WU Chao SUN Xiangshang SHANG Haijiao LIAO Wentao YAN Nan ZHOU Yun PU Yuehu |
| author_facet | LIU Junya YU Xiao WU Chao SUN Xiangshang SHANG Haijiao LIAO Wentao YAN Nan ZHOU Yun PU Yuehu |
| author_sort | LIU Junya |
| collection | DOAJ |
| description | BackgroundUltra-high dose rate (UHDR) radiation of electron or proton beam has been shown to spare normal tissues surrounding the tumors while killing tumor cells effectively which is called the FLASH effect (FE). However, the internal mechanisms of FE has not yet been fully revealed, and the optimal parameter range for its use remains unknown.PurposeThis study aims to design an UHDR cell irradiation experimental platform that provides a stable, appropriate and wide range of adjustable dose and average dose rates for exploring the FE dependence on total dose.MethodsBased on a 7 MeV medical proton linear injector, a single scattering nozzle was designed and optimized using the Monte Carlo code FLUKA. A 40-μm-thick tantalum foil, acting as both a vacuum window and a scatterer, was comprised in the nozzle with a source-to-surface distance of 26 cm. Finally, a single pulsed shoot-through UHDR cell penetration irradiation experiment was conducted by simulation using optimized parameters for this platform.ResultsThe simulation results demonstrate that the experimental platform can provide a 2 cm diameter irradiation field with a dose homogeneity of 4.9%. By adjusting the beam intensities (0.1~1 mA) and pulse widths (20~200 μs) of proton beam pulses, the dose and corresponding average dose rate of this platform can be adjusted within the range of 6~667 Gy and 3.3×105~3.3×106 Gy·s-1, respectively. Results of simulated UHDR cell irradiation experiment show that the monolayer cells can be irradiated using a single pulsed shoot-through mode with a dose rate of 3.3×105 Gy·s-1 and doses ranging from 7~40 Gy.ConclusionThis platform enables UHDR experiments to explore the FE dependence on total dose, providing further experimental data for clarifying the FE mechanisms. |
| first_indexed | 2024-03-09T03:06:12Z |
| format | Article |
| id | doaj.art-980ece6c2afd4bb2bf83f5354027162f |
| institution | Directory Open Access Journal |
| issn | 0253-3219 |
| language | zho |
| last_indexed | 2024-03-09T03:06:12Z |
| publishDate | 2023-11-01 |
| publisher | Science Press |
| record_format | Article |
| series | He jishu |
| spelling | doaj.art-980ece6c2afd4bb2bf83f5354027162f2023-12-04T07:35:42ZzhoScience PressHe jishu0253-32192023-11-01461111020111020110.11889/j.0253-3219.2023.hjs.46.1102010253-3219（2023）11-0002-11Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injectorLIU Junya0YU Xiao1WU Chao2SUN Xiangshang3SHANG Haijiao4LIAO Wentao5YAN Nan6ZHOU Yun7PU Yuehu8Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaSemicoreZKX Co. Ltd., Beijing 101111, ChinaMedical Equipment Innovation Research Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Radiation Physics and Technology, Hunan Cancer Hospital, Changsha 410013, ChinaRaySearch China, Shanghai 200120, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, ChinaMedical Equipment Innovation Research Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaBackgroundUltra-high dose rate (UHDR) radiation of electron or proton beam has been shown to spare normal tissues surrounding the tumors while killing tumor cells effectively which is called the FLASH effect (FE). However, the internal mechanisms of FE has not yet been fully revealed, and the optimal parameter range for its use remains unknown.PurposeThis study aims to design an UHDR cell irradiation experimental platform that provides a stable, appropriate and wide range of adjustable dose and average dose rates for exploring the FE dependence on total dose.MethodsBased on a 7 MeV medical proton linear injector, a single scattering nozzle was designed and optimized using the Monte Carlo code FLUKA. A 40-μm-thick tantalum foil, acting as both a vacuum window and a scatterer, was comprised in the nozzle with a source-to-surface distance of 26 cm. Finally, a single pulsed shoot-through UHDR cell penetration irradiation experiment was conducted by simulation using optimized parameters for this platform.ResultsThe simulation results demonstrate that the experimental platform can provide a 2 cm diameter irradiation field with a dose homogeneity of 4.9%. By adjusting the beam intensities (0.1~1 mA) and pulse widths (20~200 μs) of proton beam pulses, the dose and corresponding average dose rate of this platform can be adjusted within the range of 6~667 Gy and 3.3×105~3.3×106 Gy·s-1, respectively. Results of simulated UHDR cell irradiation experiment show that the monolayer cells can be irradiated using a single pulsed shoot-through mode with a dose rate of 3.3×105 Gy·s-1 and doses ranging from 7~40 Gy.ConclusionThis platform enables UHDR experiments to explore the FE dependence on total dose, providing further experimental data for clarifying the FE mechanisms.http://www.hjs.sinap.ac.cn/thesisDetails#10.11889/j.0253-3219.2023.hjs.46.110201&lang=zhflashproton therapymonte carlodesign of experimental platformmedical linear injector |
| spellingShingle | LIU Junya YU Xiao WU Chao SUN Xiangshang SHANG Haijiao LIAO Wentao YAN Nan ZHOU Yun PU Yuehu Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector He jishu flash proton therapy monte carlo design of experimental platform medical linear injector |
| title | Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector |
| title_full | Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector |
| title_fullStr | Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector |
| title_full_unstemmed | Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector |
| title_short | Design of an ultra-high dose rate cell irradiation experimental platform using a medical proton linear injector |
| title_sort | design of an ultra high dose rate cell irradiation experimental platform using a medical proton linear injector |
| topic | flash proton therapy monte carlo design of experimental platform medical linear injector |
| url | http://www.hjs.sinap.ac.cn/thesisDetails#10.11889/j.0253-3219.2023.hjs.46.110201&lang=zh |
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