Potential interactions between psychotropic drugs and alcohol and tobacco dependence
Abstract The aim of this study was to identify and analyze the potential interactions between psychotropic drugs and alcohol and tobacco addiction. A cross-sectional study was carried out on secondary data collection in a Center for Psychosocial Care in Alcohol and Other Drugs. Subjects aged 18 year...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2022-12-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100771&tlng=en |
| _version_ | 1811212760264998912 |
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| author | Diego Zapelini do Nascimento Gabriela Moreno Marques Fabiana Schuelter-Trevisol |
| author_facet | Diego Zapelini do Nascimento Gabriela Moreno Marques Fabiana Schuelter-Trevisol |
| author_sort | Diego Zapelini do Nascimento |
| collection | DOAJ |
| description | Abstract The aim of this study was to identify and analyze the potential interactions between psychotropic drugs and alcohol and tobacco addiction. A cross-sectional study was carried out on secondary data collection in a Center for Psychosocial Care in Alcohol and Other Drugs. Subjects aged 18 years old and over, with alcohol and tobacco dependence, who were taking psychotherapies were included. Medical records with the most recent prescriptions were reviewed. Potential interactions between psychotropic drugs and alcohol and tobacco were analyzed using the Micromedex database and stratified according to clinical risks and mechanisms of action. The Pearson’s Chi-square test was used to find significant associations between the variables of interest. The significance level was set at 5%. Between the 2010-2018 period, 2,322 subjects were treated at the care center. Of these, 1,020 fulfilled the inclusion criteria, out of whom 515 (50.5%) were dependent on alcohol and 310 (30.4%) were dependent on tobacco. We found 1,099 potential interactions between psychotropic drugs and alcohol and 160 potential interactions between psychotropic drugs and tobacco. In relation to alcohol dependence, psychotropic drugs interacted largely with moderate clinical risk, and pharmacokinetic mechanisms of action. In relation to tobacco dependence, high clinical risk interactions and pharmacodynamic mechanisms of action predominated. |
| first_indexed | 2024-04-12T05:34:42Z |
| format | Article |
| id | doaj.art-9814e30487184080a614662ad37dd57b |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-12T05:34:42Z |
| publishDate | 2022-12-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-9814e30487184080a614662ad37dd57b2022-12-22T03:45:54ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-12-015810.1590/s2175-97902022e20401Potential interactions between psychotropic drugs and alcohol and tobacco dependenceDiego Zapelini do Nascimentohttps://orcid.org/0000-0002-7323-185XGabriela Moreno Marqueshttps://orcid.org/0000-0001-9296-7574Fabiana Schuelter-Trevisolhttps://orcid.org/0000-0003-0997-1594Abstract The aim of this study was to identify and analyze the potential interactions between psychotropic drugs and alcohol and tobacco addiction. A cross-sectional study was carried out on secondary data collection in a Center for Psychosocial Care in Alcohol and Other Drugs. Subjects aged 18 years old and over, with alcohol and tobacco dependence, who were taking psychotherapies were included. Medical records with the most recent prescriptions were reviewed. Potential interactions between psychotropic drugs and alcohol and tobacco were analyzed using the Micromedex database and stratified according to clinical risks and mechanisms of action. The Pearson’s Chi-square test was used to find significant associations between the variables of interest. The significance level was set at 5%. Between the 2010-2018 period, 2,322 subjects were treated at the care center. Of these, 1,020 fulfilled the inclusion criteria, out of whom 515 (50.5%) were dependent on alcohol and 310 (30.4%) were dependent on tobacco. We found 1,099 potential interactions between psychotropic drugs and alcohol and 160 potential interactions between psychotropic drugs and tobacco. In relation to alcohol dependence, psychotropic drugs interacted largely with moderate clinical risk, and pharmacokinetic mechanisms of action. In relation to tobacco dependence, high clinical risk interactions and pharmacodynamic mechanisms of action predominated.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100771&tlng=enAlcoholismDrug interactionsPharmacoepidemiologyTobacco use disorderSubstance-related disorders |
| spellingShingle | Diego Zapelini do Nascimento Gabriela Moreno Marques Fabiana Schuelter-Trevisol Potential interactions between psychotropic drugs and alcohol and tobacco dependence Brazilian Journal of Pharmaceutical Sciences Alcoholism Drug interactions Pharmacoepidemiology Tobacco use disorder Substance-related disorders |
| title | Potential interactions between psychotropic drugs and alcohol and tobacco dependence |
| title_full | Potential interactions between psychotropic drugs and alcohol and tobacco dependence |
| title_fullStr | Potential interactions between psychotropic drugs and alcohol and tobacco dependence |
| title_full_unstemmed | Potential interactions between psychotropic drugs and alcohol and tobacco dependence |
| title_short | Potential interactions between psychotropic drugs and alcohol and tobacco dependence |
| title_sort | potential interactions between psychotropic drugs and alcohol and tobacco dependence |
| topic | Alcoholism Drug interactions Pharmacoepidemiology Tobacco use disorder Substance-related disorders |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100771&tlng=en |
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