ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?
Chronic kidney disease (CKD) is a major health problem, affecting millions of people worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from significantly increased cardiovascular disease (CVD) morbidity and mortality, mainly due to accelerated atherosclerosis developme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7309 |
| _version_ | 1797605096045936640 |
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| author | Sanne L. Maas Marjo M. P. C. Donners Emiel P. C. van der Vorst |
| author_facet | Sanne L. Maas Marjo M. P. C. Donners Emiel P. C. van der Vorst |
| author_sort | Sanne L. Maas |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a major health problem, affecting millions of people worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from significantly increased cardiovascular disease (CVD) morbidity and mortality, mainly due to accelerated atherosclerosis development. Indeed, CKD not only affects the kidneys, in which injury and maladaptive repair processes lead to local inflammation and fibrosis, but also causes systemic inflammation and altered mineral bone metabolism leading to vascular dysfunction, calcification, and thus, accelerated atherosclerosis. Although CKD and CVD individually have been extensively studied, relatively little research has studied the link between both diseases. This narrative review focuses on the role of a disintegrin and metalloproteases (ADAM) 10 and ADAM17 in CKD and CVD and will for the first time shed light on their role in CKD-induced CVD. By cleaving cell surface molecules, these enzymes regulate not only cellular sensitivity to their micro-environment (in case of receptor cleavage), but also release soluble ectodomains that can exert agonistic or antagonistic functions, both locally and systemically. Although the cell-specific roles of ADAM10 and ADAM17 in CVD, and to a lesser extent in CKD, have been explored, their impact on CKD-induced CVD is likely, yet remains to be elucidated. |
| first_indexed | 2024-03-11T04:56:18Z |
| format | Article |
| id | doaj.art-9814f47e626f4bfcb01acbf241ff1c61 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:18Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9814f47e626f4bfcb01acbf241ff1c612023-11-17T19:38:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248730910.3390/ijms24087309ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?Sanne L. Maas0Marjo M. P. C. Donners1Emiel P. C. van der Vorst2Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanyDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, 6229 ER Maastricht, The NetherlandsInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanyChronic kidney disease (CKD) is a major health problem, affecting millions of people worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from significantly increased cardiovascular disease (CVD) morbidity and mortality, mainly due to accelerated atherosclerosis development. Indeed, CKD not only affects the kidneys, in which injury and maladaptive repair processes lead to local inflammation and fibrosis, but also causes systemic inflammation and altered mineral bone metabolism leading to vascular dysfunction, calcification, and thus, accelerated atherosclerosis. Although CKD and CVD individually have been extensively studied, relatively little research has studied the link between both diseases. This narrative review focuses on the role of a disintegrin and metalloproteases (ADAM) 10 and ADAM17 in CKD and CVD and will for the first time shed light on their role in CKD-induced CVD. By cleaving cell surface molecules, these enzymes regulate not only cellular sensitivity to their micro-environment (in case of receptor cleavage), but also release soluble ectodomains that can exert agonistic or antagonistic functions, both locally and systemically. Although the cell-specific roles of ADAM10 and ADAM17 in CVD, and to a lesser extent in CKD, have been explored, their impact on CKD-induced CVD is likely, yet remains to be elucidated.https://www.mdpi.com/1422-0067/24/8/7309a disintegrin and metalloproteasechronic kidney diseasecardiovascular diseasesatherosclerosis |
| spellingShingle | Sanne L. Maas Marjo M. P. C. Donners Emiel P. C. van der Vorst ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? International Journal of Molecular Sciences a disintegrin and metalloprotease chronic kidney disease cardiovascular diseases atherosclerosis |
| title | ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? |
| title_full | ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? |
| title_fullStr | ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? |
| title_full_unstemmed | ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? |
| title_short | ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? |
| title_sort | adam10 and adam17 major regulators of chronic kidney disease induced atherosclerosis |
| topic | a disintegrin and metalloprotease chronic kidney disease cardiovascular diseases atherosclerosis |
| url | https://www.mdpi.com/1422-0067/24/8/7309 |
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