Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment
Osteoporosis is a major challenge to oral implants, and this study focused on improving the osseointegration ability of titanium (Ti) implants in osteoporosis environment via surface modification, including doping of strontium ion and preparation of nanoscale surface feature. Our previous studies ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1011482/full |
| _version_ | 1818050218327801856 |
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| author | Tengyu Geng Tengyu Geng Yiru Wang Yiru Wang Kaili Lin Cheng Zhang Jing Wang Ya Liu Changyong Yuan Changyong Yuan Penglai Wang Penglai Wang |
| author_facet | Tengyu Geng Tengyu Geng Yiru Wang Yiru Wang Kaili Lin Cheng Zhang Jing Wang Ya Liu Changyong Yuan Changyong Yuan Penglai Wang Penglai Wang |
| author_sort | Tengyu Geng |
| collection | DOAJ |
| description | Osteoporosis is a major challenge to oral implants, and this study focused on improving the osseointegration ability of titanium (Ti) implants in osteoporosis environment via surface modification, including doping of strontium ion and preparation of nanoscale surface feature. Our previous studies have shown that strontium (Sr) ions can enhance osteogenic activity. Therefore, we aimed to comprehensively evaluate the effect of hydrothermal treatment of Sr-doped titanium implant coating on bone-binding properties in the microenvironment of osteoporosis in this study. We fabricated Sr-doped nanocoating (AHT-Sr) onto the surface of titanium implants via hydrothermal reaction. The rough Sr-doping had good biological functions and could apparently promote osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (OVX-BMSCs). Most importantly, AHT-Sr significantly promoted bone integration in the osteoporosis environment. This study provides an effective approach to implant surface modification for better osseointegration in an osteoporotic environment. |
| first_indexed | 2024-12-10T10:49:59Z |
| format | Article |
| id | doaj.art-981679e142104eb2a46cc4a017c1cbd9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T10:49:59Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-981679e142104eb2a46cc4a017c1cbd92022-12-22T01:52:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.10114821011482Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironmentTengyu Geng0Tengyu Geng1Yiru Wang2Yiru Wang3Kaili Lin4Cheng Zhang5Jing Wang6Ya Liu7Changyong Yuan8Changyong Yuan9Penglai Wang10Penglai Wang11School of Stomatology, Xuzhou Medical University, Xuzhou, ChinaDepartment of Dental Implant, The Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, ChinaSchool of Stomatology, Xuzhou Medical University, Xuzhou, ChinaDepartment of Dental Implant, The Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, ChinaSchool of Stomatology, Xuzhou Medical University, Xuzhou, ChinaSchool of Stomatology, Xuzhou Medical University, Xuzhou, ChinaSchool of Stomatology, Xuzhou Medical University, Xuzhou, ChinaSchool of Stomatology, Xuzhou Medical University, Xuzhou, ChinaDepartment of Dental Implant, The Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, ChinaSchool of Stomatology, Xuzhou Medical University, Xuzhou, ChinaDepartment of Dental Implant, The Affiliated Stomatological Hospital of Xuzhou Medical University, Xuzhou, ChinaOsteoporosis is a major challenge to oral implants, and this study focused on improving the osseointegration ability of titanium (Ti) implants in osteoporosis environment via surface modification, including doping of strontium ion and preparation of nanoscale surface feature. Our previous studies have shown that strontium (Sr) ions can enhance osteogenic activity. Therefore, we aimed to comprehensively evaluate the effect of hydrothermal treatment of Sr-doped titanium implant coating on bone-binding properties in the microenvironment of osteoporosis in this study. We fabricated Sr-doped nanocoating (AHT-Sr) onto the surface of titanium implants via hydrothermal reaction. The rough Sr-doping had good biological functions and could apparently promote osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells (OVX-BMSCs). Most importantly, AHT-Sr significantly promoted bone integration in the osteoporosis environment. This study provides an effective approach to implant surface modification for better osseointegration in an osteoporotic environment.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1011482/fulltitanium implantssurface modificationosteoporosisstrontiumosseointegration |
| spellingShingle | Tengyu Geng Tengyu Geng Yiru Wang Yiru Wang Kaili Lin Cheng Zhang Jing Wang Ya Liu Changyong Yuan Changyong Yuan Penglai Wang Penglai Wang Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment Frontiers in Bioengineering and Biotechnology titanium implants surface modification osteoporosis strontium osseointegration |
| title | Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment |
| title_full | Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment |
| title_fullStr | Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment |
| title_full_unstemmed | Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment |
| title_short | Strontium-doping promotes bone bonding of titanium implants in osteoporotic microenvironment |
| title_sort | strontium doping promotes bone bonding of titanium implants in osteoporotic microenvironment |
| topic | titanium implants surface modification osteoporosis strontium osseointegration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1011482/full |
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