QbD Based Media Development for the Production of Fab Fragments in <i>E. coli</i>

QbD Based Media Development for the Production of Fab Fragments in <i>E. coli</i>

Ranibizumab is a biotherapeutic Fab fragment used for the treatment of age-related macular degeneration and macular oedema. It is currently expressed in the gram-negative bacterium, <i>Escherichia coli</i>. However, low expression levels result in a high manufacturing cost. The protein e...

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Bibliographic Details
Main Authors:	Deepak Kumar, Jyoti Batra, Claire Komives, Anurag S. Rathore
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Bioengineering
Subjects:	quality by design Ranibizumab design of experiments media development
Online Access:	https://www.mdpi.com/2306-5354/6/2/29

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