Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension
We present a case of a 65-year-old Hispanic man with a history of disseminated cutaneous coccidioidomycosis who presented to the emergency room for progressively worsening abdominal pain associated with shortness of breath. The patient was found to have pleural effusion and moderate ascites on physi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-09-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709615609385 |
| _version_ | 1818280087356702720 |
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| author | Saman Ratnayake MD Ali Ammar MD Rodd Rezvani BS Greti Petersen MD |
| author_facet | Saman Ratnayake MD Ali Ammar MD Rodd Rezvani BS Greti Petersen MD |
| author_sort | Saman Ratnayake MD |
| collection | DOAJ |
| description | We present a case of a 65-year-old Hispanic man with a history of disseminated cutaneous coccidioidomycosis who presented to the emergency room for progressively worsening abdominal pain associated with shortness of breath. The patient was found to have pleural effusion and moderate ascites on physical examination. Abdominal ultrasound and computed tomography scan were consistent with moderate ascites and portal hypertension but negative for both liver cirrhosis and for venous or arterial thrombosis. Cytology of ascitic fluid was suggestive of portal hypertension and was negative for infection. Subsequent, thoracentesis was suggestive of exudative effusion and also negative for infection. Liver biopsy confirmed the absence of cirrhosis. Complete blood count indicated pancytopenia, whereas bone marrow biopsy and flow cytometry were suggestive of marginal zone lymphoma (MZL). Clinically, the patient’s shortness of breath was resolved by thoracentesis and paracentesis; however, his abdominal pain persisted. A diagnosis of idiopathic noncirrhotic portal hypertension in the setting of splenic MZL was made. The patient was transferred to a higher level of care for splenectomy; however, he missed multiple appointments. Since discharge, the patient has been seen in the outpatient setting and states that he is controlling his disease with diet and exercise; however, he continues to complain of intermittent shortness of breath with exertion. |
| first_indexed | 2024-12-12T23:43:39Z |
| format | Article |
| id | doaj.art-98190469bbfd4b2a805fc28c580a952f |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-12T23:43:39Z |
| publishDate | 2015-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-98190469bbfd4b2a805fc28c580a952f2022-12-22T00:07:00ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962015-09-01310.1177/232470961560938510.1177_2324709615609385Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal HypertensionSaman Ratnayake MD0Ali Ammar MD1Rodd Rezvani BS2Greti Petersen MD3Kern Medical Center, Bakersfield, CA, USAKern Medical Center, Bakersfield, CA, USAKern Medical Center, Bakersfield, CA, USAKern Medical Center, Bakersfield, CA, USAWe present a case of a 65-year-old Hispanic man with a history of disseminated cutaneous coccidioidomycosis who presented to the emergency room for progressively worsening abdominal pain associated with shortness of breath. The patient was found to have pleural effusion and moderate ascites on physical examination. Abdominal ultrasound and computed tomography scan were consistent with moderate ascites and portal hypertension but negative for both liver cirrhosis and for venous or arterial thrombosis. Cytology of ascitic fluid was suggestive of portal hypertension and was negative for infection. Subsequent, thoracentesis was suggestive of exudative effusion and also negative for infection. Liver biopsy confirmed the absence of cirrhosis. Complete blood count indicated pancytopenia, whereas bone marrow biopsy and flow cytometry were suggestive of marginal zone lymphoma (MZL). Clinically, the patient’s shortness of breath was resolved by thoracentesis and paracentesis; however, his abdominal pain persisted. A diagnosis of idiopathic noncirrhotic portal hypertension in the setting of splenic MZL was made. The patient was transferred to a higher level of care for splenectomy; however, he missed multiple appointments. Since discharge, the patient has been seen in the outpatient setting and states that he is controlling his disease with diet and exercise; however, he continues to complain of intermittent shortness of breath with exertion.https://doi.org/10.1177/2324709615609385 |
| spellingShingle | Saman Ratnayake MD Ali Ammar MD Rodd Rezvani BS Greti Petersen MD Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension Journal of Investigative Medicine High Impact Case Reports |
| title | Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension |
| title_full | Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension |
| title_fullStr | Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension |
| title_full_unstemmed | Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension |
| title_short | Splenic Marginal Zone Lymphoma in the Setting of Noncirrhotic Portal Hypertension |
| title_sort | splenic marginal zone lymphoma in the setting of noncirrhotic portal hypertension |
| url | https://doi.org/10.1177/2324709615609385 |
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