IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance
Innate lymphoid cells (ILCs) are mainly composed of natural killer (NK) cells and helper-like lymphoid cells, which play a vital role in maintaining tissue homeostasis, enhancing adaptive immunity and regulating tissue inflammation. Alteration of the distribution and function of ILCs subgroups are c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.650200/full |
| _version_ | 1818928683541331968 |
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| author | Hui Sun Yuzhang Wu Yi Zhang Bing Ni |
| author_facet | Hui Sun Yuzhang Wu Yi Zhang Bing Ni |
| author_sort | Hui Sun |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs) are mainly composed of natural killer (NK) cells and helper-like lymphoid cells, which play a vital role in maintaining tissue homeostasis, enhancing adaptive immunity and regulating tissue inflammation. Alteration of the distribution and function of ILCs subgroups are closely related to the pathogenesis of inflammatory diseases and cancers. Interleukin-10 (IL-10) is a highly pleiotropic cytokine, and can be secreted by several cell types, among of which ILCs are recently verified to be a key source of IL-10. So far, the stable production of IL-10 can only be observed in certain NK subsets and ILC2s. Though the regulatory mechanisms for ILCs to produce IL-10 are pivotal for understanding ILCs and potential intervenes of diseases, which however is largely unknown yet. The published studies show that ILCs do not share exactly the same mechanisms for IL-10 production with helper T cells. In this review, the molecular mechanisms regulating IL-10 production in NK cells and ILC2s are discussed in details for the first time, and the role of IL-10-producing ILCs in diseases such as infections, allergies, and cancers are summarized. |
| first_indexed | 2024-12-20T03:32:48Z |
| format | Article |
| id | doaj.art-98197cad56f848d5a7276ca531ebc68d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T03:32:48Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-98197cad56f848d5a7276ca531ebc68d2022-12-21T19:54:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.650200650200IL-10-Producing ILCs: Molecular Mechanisms and Disease RelevanceHui Sun0Yuzhang Wu1Yi Zhang2Bing Ni3Department of Pathophysiology, Third Military Medical University, Chongqing, ChinaChongqing International Institute for Immunology, Chongqing, ChinaChongqing International Institute for Immunology, Chongqing, ChinaDepartment of Pathophysiology, Third Military Medical University, Chongqing, ChinaInnate lymphoid cells (ILCs) are mainly composed of natural killer (NK) cells and helper-like lymphoid cells, which play a vital role in maintaining tissue homeostasis, enhancing adaptive immunity and regulating tissue inflammation. Alteration of the distribution and function of ILCs subgroups are closely related to the pathogenesis of inflammatory diseases and cancers. Interleukin-10 (IL-10) is a highly pleiotropic cytokine, and can be secreted by several cell types, among of which ILCs are recently verified to be a key source of IL-10. So far, the stable production of IL-10 can only be observed in certain NK subsets and ILC2s. Though the regulatory mechanisms for ILCs to produce IL-10 are pivotal for understanding ILCs and potential intervenes of diseases, which however is largely unknown yet. The published studies show that ILCs do not share exactly the same mechanisms for IL-10 production with helper T cells. In this review, the molecular mechanisms regulating IL-10 production in NK cells and ILC2s are discussed in details for the first time, and the role of IL-10-producing ILCs in diseases such as infections, allergies, and cancers are summarized.https://www.frontiersin.org/articles/10.3389/fimmu.2021.650200/fulltranscriptional regulationIL-10ILC2NK cellsinnate lymphoid cells |
| spellingShingle | Hui Sun Yuzhang Wu Yi Zhang Bing Ni IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance Frontiers in Immunology transcriptional regulation IL-10 ILC2 NK cells innate lymphoid cells |
| title | IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance |
| title_full | IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance |
| title_fullStr | IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance |
| title_full_unstemmed | IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance |
| title_short | IL-10-Producing ILCs: Molecular Mechanisms and Disease Relevance |
| title_sort | il 10 producing ilcs molecular mechanisms and disease relevance |
| topic | transcriptional regulation IL-10 ILC2 NK cells innate lymphoid cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.650200/full |
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