Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus
Alzheimer’s disease (AD) and diabetes mellitus (DM) are known to have a shared molecular mechanism. We aimed to identify shared blood transcriptomic signatures between AD and DM. Blood expression datasets for each disease were combined and a co-expression network was used to construct modules consis...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/1/34 |
| _version_ | 1797542409631956992 |
|---|---|
| author | Taesic Lee Hyunju Lee |
| author_facet | Taesic Lee Hyunju Lee |
| author_sort | Taesic Lee |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) and diabetes mellitus (DM) are known to have a shared molecular mechanism. We aimed to identify shared blood transcriptomic signatures between AD and DM. Blood expression datasets for each disease were combined and a co-expression network was used to construct modules consisting of genes with similar expression patterns. For each module, a gene regulatory network based on gene expression and protein-protein interactions was established to identify hub genes. We selected one module, where <i>COPS4</i>, <i>PSMA6</i>, <i>GTF2B</i>, <i>GTF2F2</i>, and <i>SSB</i> were identified as dysregulated transcription factors that were common between AD and DM. These five genes were also differentially co-expressed in disease-related tissues, such as the brain in AD and the pancreas in DM. Our study identified gene modules that were dysregulated in both AD and DM blood samples, which may contribute to reveal common pathophysiology between two diseases. |
| first_indexed | 2024-03-10T13:30:11Z |
| format | Article |
| id | doaj.art-981e2ae69fda47f5aebc1eddc92c9467 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T13:30:11Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-981e2ae69fda47f5aebc1eddc92c94672023-11-21T08:07:01ZengMDPI AGBiomedicines2227-90592021-01-01913410.3390/biomedicines9010034Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes MellitusTaesic Lee0Hyunju Lee1Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, KoreaAlzheimer’s disease (AD) and diabetes mellitus (DM) are known to have a shared molecular mechanism. We aimed to identify shared blood transcriptomic signatures between AD and DM. Blood expression datasets for each disease were combined and a co-expression network was used to construct modules consisting of genes with similar expression patterns. For each module, a gene regulatory network based on gene expression and protein-protein interactions was established to identify hub genes. We selected one module, where <i>COPS4</i>, <i>PSMA6</i>, <i>GTF2B</i>, <i>GTF2F2</i>, and <i>SSB</i> were identified as dysregulated transcription factors that were common between AD and DM. These five genes were also differentially co-expressed in disease-related tissues, such as the brain in AD and the pancreas in DM. Our study identified gene modules that were dysregulated in both AD and DM blood samples, which may contribute to reveal common pathophysiology between two diseases.https://www.mdpi.com/2227-9059/9/1/34Alzheimer’s diseasediabetes mellitusblood gene expression |
| spellingShingle | Taesic Lee Hyunju Lee Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus Biomedicines Alzheimer’s disease diabetes mellitus blood gene expression |
| title | Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus |
| title_full | Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus |
| title_fullStr | Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus |
| title_full_unstemmed | Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus |
| title_short | Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus |
| title_sort | shared blood transcriptomic signatures between alzheimer s disease and diabetes mellitus |
| topic | Alzheimer’s disease diabetes mellitus blood gene expression |
| url | https://www.mdpi.com/2227-9059/9/1/34 |
| work_keys_str_mv | AT taesiclee sharedbloodtranscriptomicsignaturesbetweenalzheimersdiseaseanddiabetesmellitus AT hyunjulee sharedbloodtranscriptomicsignaturesbetweenalzheimersdiseaseanddiabetesmellitus |