Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease
Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflamma...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.865777/full |
| _version_ | 1818535586581970944 |
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| author | Reza Yarani Reza Yarani Ali Shojaeian Oana Palasca Oana Palasca Oana Palasca Nadezhda T. Doncheva Nadezhda T. Doncheva Nadezhda T. Doncheva Lars Juhl Jensen Lars Juhl Jensen Jan Gorodkin Jan Gorodkin Flemming Pociot Flemming Pociot Flemming Pociot Flemming Pociot |
| author_facet | Reza Yarani Reza Yarani Ali Shojaeian Oana Palasca Oana Palasca Oana Palasca Nadezhda T. Doncheva Nadezhda T. Doncheva Nadezhda T. Doncheva Lars Juhl Jensen Lars Juhl Jensen Jan Gorodkin Jan Gorodkin Flemming Pociot Flemming Pociot Flemming Pociot Flemming Pociot |
| author_sort | Reza Yarani |
| collection | DOAJ |
| description | Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. This review summarizes current knowledge of differentially expressed miRNAs in mucosal tissues and peripheral blood of patients with ulcerative colitis and Crohn’s disease. We combined comprehensive literature curation with computational meta-analysis of publicly available high-throughput datasets to obtain a consensus set of miRNAs consistently differentially expressed in mucosal tissues. We further describe the role of the most relevant differentially expressed miRNAs in IBD, extract their potential targets involved in IBD, and highlight their diagnostic and therapeutic potential for future investigations. |
| first_indexed | 2024-12-11T18:26:52Z |
| format | Article |
| id | doaj.art-981e58615b4d4e998a483aaa98d7b0dd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T18:26:52Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-981e58615b4d4e998a483aaa98d7b0dd2022-12-22T00:55:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.865777865777Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s DiseaseReza Yarani0Reza Yarani1Ali Shojaeian2Oana Palasca3Oana Palasca4Oana Palasca5Nadezhda T. Doncheva6Nadezhda T. Doncheva7Nadezhda T. Doncheva8Lars Juhl Jensen9Lars Juhl Jensen10Jan Gorodkin11Jan Gorodkin12Flemming Pociot13Flemming Pociot14Flemming Pociot15Flemming Pociot16Translational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, DenmarkInterventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, United StatesResearch Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, IranNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkCenter for Non-Coding RNA in Technology and Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkCenter for Non-Coding RNA in Technology and Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DenmarkCenter for Non-Coding RNA in Technology and Health, University of Copenhagen, Copenhagen, DenmarkCenter for Non-Coding RNA in Technology and Health, University of Copenhagen, Copenhagen, DenmarkDepartment of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkTranslational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, DenmarkCenter for Non-Coding RNA in Technology and Health, University of Copenhagen, Copenhagen, DenmarkCopenhagen Diabetes Research Center, Department of Pediatrics, Herlev University Hospital, Herlev, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDifferential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. This review summarizes current knowledge of differentially expressed miRNAs in mucosal tissues and peripheral blood of patients with ulcerative colitis and Crohn’s disease. We combined comprehensive literature curation with computational meta-analysis of publicly available high-throughput datasets to obtain a consensus set of miRNAs consistently differentially expressed in mucosal tissues. We further describe the role of the most relevant differentially expressed miRNAs in IBD, extract their potential targets involved in IBD, and highlight their diagnostic and therapeutic potential for future investigations.https://www.frontiersin.org/articles/10.3389/fimmu.2022.865777/fullmiRNAulcerative colitisCrohn’s diseaseinflammatory bowel disaseTranscriptomics |
| spellingShingle | Reza Yarani Reza Yarani Ali Shojaeian Oana Palasca Oana Palasca Oana Palasca Nadezhda T. Doncheva Nadezhda T. Doncheva Nadezhda T. Doncheva Lars Juhl Jensen Lars Juhl Jensen Jan Gorodkin Jan Gorodkin Flemming Pociot Flemming Pociot Flemming Pociot Flemming Pociot Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease Frontiers in Immunology miRNA ulcerative colitis Crohn’s disease inflammatory bowel disase Transcriptomics |
| title | Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease |
| title_full | Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease |
| title_fullStr | Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease |
| title_full_unstemmed | Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease |
| title_short | Differentially Expressed miRNAs in Ulcerative Colitis and Crohn’s Disease |
| title_sort | differentially expressed mirnas in ulcerative colitis and crohn s disease |
| topic | miRNA ulcerative colitis Crohn’s disease inflammatory bowel disase Transcriptomics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.865777/full |
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