| Summary: | Poorly characterized by non-invasive diagnostic imaging techniques, pulmonary hypertension (PHT) is commonly associated with changes in vascular hemodynamics and remodeling of pulmonary artery architecture. These disease phenotypes represent potential biomarkers of interest in clinical environment. In this retrospective clinical study, 33 patients with pulmonary hypertension and seventeen controls were recruited. Architectural remodeling was characterized using 3D-contrast enhanced angiogram via the measurement of pulmonary artery diameters, bifurcation distances, and angles. Hemodynamics were characterized using 4D-flow magnetic resonance imaging (MRI) via wall shear stress, kinetic energy, vorticity, and directional flow dynamics. Parameters were compared using independent samples student’s t-tests. Correlational analysis was performed using Pearson’s correlation. PHT patients demonstrated dilation in the main and right branch of the pulmonary artery (<i>p</i> < 0.05). Furthermore, these patients also exhibited increases in bifurcation distances in the left and right pulmonary arteries (<i>p</i> < 0.05). Wall shear stress, maximum kinetic energy, and energy loss were decreased in the pulmonary artery (<i>p</i> < 0.001). Correlations were observed between peak velocities and right ventricle ejection fraction (r = 0.527, <i>p</i> < 0.05). These findings suggest that pulmonary artery remodeling and hemodynamic changes may possess clinical utility as MRI biomarkers for PHT.
|
|---|