Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis
Background. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted this meta-analysis to assess the association between serum IL-6 concentrations an...
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PeerJ Inc.
2015-08-01
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| author | Jia Wei Xiao-feng Xiong Yi-hua Lin Bi-xia Zheng De-yun Cheng |
| author_facet | Jia Wei Xiao-feng Xiong Yi-hua Lin Bi-xia Zheng De-yun Cheng |
| author_sort | Jia Wei |
| collection | DOAJ |
| description | Background. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted this meta-analysis to assess the association between serum IL-6 concentrations and COPD.Methods. PubMed and Embase were searched for eligible studies. Data were extracted by two investigators (Wei J, Xiong XF) independently and analyzed using Review Manager 5.3 and STATA 12.0 software. Standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated.Results. Thirty-three studies were included in this meta-analysis. The serum IL-6 concentrations were higher in patients with stable COPD than healthy controls (SMD = 0.65, 95% CI [0.51–0.79]). COPD patients without major comorbidities also showed higher IL-6 levels than healthy controls (SMD = 0.74, 95% CI [0.56–0.91]). COPD patients with an forced expiratory volume in one second (FEV1) of either <50% predicted or >50% predicted had increased IL-6 concentrations compared to healthy controls (SMD = 0.77, 95% CI [0.48–1.05], SMD = 1.01, 95% CI [0.43–1.59], respectively). The serum IL-6 concentrations between mild-moderate and severe-very severe COPD patient groups were not found to be significant (SMD = −0.1, 95% CI [−0.65–0.44]).Conclusions. This meta-analysis indicated that patients with stable COPD had higher serum IL-6 concentrations than healthy controls. No evidence showing positive or negative association between IL-6 concentrations and the severity of pulmonary function impairment was found. The correlation between IL-6 levels and pulmonary function was weak in different severities of stable COPD patients. |
| first_indexed | 2024-03-09T08:04:37Z |
| format | Article |
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| language | English |
| last_indexed | 2024-03-09T08:04:37Z |
| publishDate | 2015-08-01 |
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| spelling | doaj.art-9820508faf184ad0972f0797e5027f832023-12-03T00:23:52ZengPeerJ Inc.PeerJ2167-83592015-08-013e119910.7717/peerj.1199Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysisJia Wei0Xiao-feng Xiong1Yi-hua Lin2Bi-xia Zheng3De-yun Cheng4Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Respiratory Medicine, First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaDepartment of Respiratory Medicine, Third People’s Hospital, Chengdu, Sichuan, ChinaDepartment of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaBackground. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted this meta-analysis to assess the association between serum IL-6 concentrations and COPD.Methods. PubMed and Embase were searched for eligible studies. Data were extracted by two investigators (Wei J, Xiong XF) independently and analyzed using Review Manager 5.3 and STATA 12.0 software. Standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated.Results. Thirty-three studies were included in this meta-analysis. The serum IL-6 concentrations were higher in patients with stable COPD than healthy controls (SMD = 0.65, 95% CI [0.51–0.79]). COPD patients without major comorbidities also showed higher IL-6 levels than healthy controls (SMD = 0.74, 95% CI [0.56–0.91]). COPD patients with an forced expiratory volume in one second (FEV1) of either <50% predicted or >50% predicted had increased IL-6 concentrations compared to healthy controls (SMD = 0.77, 95% CI [0.48–1.05], SMD = 1.01, 95% CI [0.43–1.59], respectively). The serum IL-6 concentrations between mild-moderate and severe-very severe COPD patient groups were not found to be significant (SMD = −0.1, 95% CI [−0.65–0.44]).Conclusions. This meta-analysis indicated that patients with stable COPD had higher serum IL-6 concentrations than healthy controls. No evidence showing positive or negative association between IL-6 concentrations and the severity of pulmonary function impairment was found. The correlation between IL-6 levels and pulmonary function was weak in different severities of stable COPD patients.https://peerj.com/articles/1199.pdfMeta-analysisChronic obstructive pulmonary diseaseSystemic inflammationInterleukin-6Pulmonary function |
| spellingShingle | Jia Wei Xiao-feng Xiong Yi-hua Lin Bi-xia Zheng De-yun Cheng Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis PeerJ Meta-analysis Chronic obstructive pulmonary disease Systemic inflammation Interleukin-6 Pulmonary function |
| title | Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis |
| title_full | Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis |
| title_fullStr | Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis |
| title_full_unstemmed | Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis |
| title_short | Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis |
| title_sort | association between serum interleukin 6 concentrations and chronic obstructive pulmonary disease a systematic review and meta analysis |
| topic | Meta-analysis Chronic obstructive pulmonary disease Systemic inflammation Interleukin-6 Pulmonary function |
| url | https://peerj.com/articles/1199.pdf |
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