Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model
Purpose In this study, we developed a novel nitinol-actuated surgical instrument to conduct laparoscopic renal denervation for the treatment of resistant hypertension. We investigated whether shape and temperature settings of nitinol specimens fit well into the design goals. Furthermore, we conducte...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2020.1767806 |
| _version_ | 1819146109346381824 |
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| author | Donghyun Yim Jinhwan Baik Sangyong Lee Sunchoel Yang Chang Wook Jeong Sung-Min Park |
| author_facet | Donghyun Yim Jinhwan Baik Sangyong Lee Sunchoel Yang Chang Wook Jeong Sung-Min Park |
| author_sort | Donghyun Yim |
| collection | DOAJ |
| description | Purpose In this study, we developed a novel nitinol-actuated surgical instrument to conduct laparoscopic renal denervation for the treatment of resistant hypertension. We investigated whether shape and temperature settings of nitinol specimens fit well into the design goals. Furthermore, we conducted a pilot study to validate the mechanical and physiological performance of nerve ablation without damaging the renal artery. Method Tensile tests were performed to observe temperature-dependent thermomechanical properties and the original shape of nitinol specimens was set considering our design goal. We performed strain gage experiments to measure bending strain. We developed surgical instrument and operated laparoscopic renal denervation in a swine model. Subsequent impedance spectroscopy experiments were conducted to measure changes in impedance magnitudes during the operation and histological analyses were performed to visualize thermogenic damage to arteries and nerves. Results Tensile testing showed that the shape memory effect begins above 37 °C. Measured strains on nitinol surfaces were 2.10% ± 0.769%, below the strain limit of 8%. Impedance spectroscopy experiments showed decreases in magnitude in all six trials. After operation of laparoscopic renal denervation following the protocol, renal arteries and nerves were harvested and thermogenic damage was observed in nerves but not arteries. Conclusion We developed a novel nitinol-actuated surgical instrument with which to perform laparoscopic renal denervation. The feasibility of our device was verified using thermomechanical analyses of nitinol, and assessments of mechanical and physiological performance. Our device could be used in other laparoscopic procedures that require large degrees of freedom while restricting to trocar size. |
| first_indexed | 2024-12-22T13:08:42Z |
| format | Article |
| id | doaj.art-9820a2b2dd894f51984b608c02fe6eac |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-22T13:08:42Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-9820a2b2dd894f51984b608c02fe6eac2022-12-21T18:24:48ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572020-01-0137157358410.1080/02656736.2020.17678061767806Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival modelDonghyun Yim0Jinhwan Baik1Sangyong Lee2Sunchoel Yang3Chang Wook Jeong4Sung-Min Park5Department of Creative IT Engineering, POSTECHDepartment of Creative IT Engineering, POSTECHDepartment of Prototype Production, Osong Medical Innovation FoundationDepartment of Prototype Production, Osong Medical Innovation FoundationDepartment of Urology, Seoul National University HospitalDepartment of Creative IT Engineering, POSTECHPurpose In this study, we developed a novel nitinol-actuated surgical instrument to conduct laparoscopic renal denervation for the treatment of resistant hypertension. We investigated whether shape and temperature settings of nitinol specimens fit well into the design goals. Furthermore, we conducted a pilot study to validate the mechanical and physiological performance of nerve ablation without damaging the renal artery. Method Tensile tests were performed to observe temperature-dependent thermomechanical properties and the original shape of nitinol specimens was set considering our design goal. We performed strain gage experiments to measure bending strain. We developed surgical instrument and operated laparoscopic renal denervation in a swine model. Subsequent impedance spectroscopy experiments were conducted to measure changes in impedance magnitudes during the operation and histological analyses were performed to visualize thermogenic damage to arteries and nerves. Results Tensile testing showed that the shape memory effect begins above 37 °C. Measured strains on nitinol surfaces were 2.10% ± 0.769%, below the strain limit of 8%. Impedance spectroscopy experiments showed decreases in magnitude in all six trials. After operation of laparoscopic renal denervation following the protocol, renal arteries and nerves were harvested and thermogenic damage was observed in nerves but not arteries. Conclusion We developed a novel nitinol-actuated surgical instrument with which to perform laparoscopic renal denervation. The feasibility of our device was verified using thermomechanical analyses of nitinol, and assessments of mechanical and physiological performance. Our device could be used in other laparoscopic procedures that require large degrees of freedom while restricting to trocar size.http://dx.doi.org/10.1080/02656736.2020.1767806hypertensionlaparoscopic instrumentnitinolradiofrequency ablationrenal denervation |
| spellingShingle | Donghyun Yim Jinhwan Baik Sangyong Lee Sunchoel Yang Chang Wook Jeong Sung-Min Park Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model International Journal of Hyperthermia hypertension laparoscopic instrument nitinol radiofrequency ablation renal denervation |
| title | Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model |
| title_full | Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model |
| title_fullStr | Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model |
| title_full_unstemmed | Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model |
| title_short | Development of a nitinol-actuated surgical instrument for laparoscopic renal denervation: feasibility test in a swine survival model |
| title_sort | development of a nitinol actuated surgical instrument for laparoscopic renal denervation feasibility test in a swine survival model |
| topic | hypertension laparoscopic instrument nitinol radiofrequency ablation renal denervation |
| url | http://dx.doi.org/10.1080/02656736.2020.1767806 |
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