Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer
Abstract Background Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC)....
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4324 |
| _version_ | 1798034526002216960 |
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| author | Stacey A. Kenfield Erin L. Van Blarigan Neil Panchal Alexander Bang Li Zhang Rebecca E. Graff Yea‐Hung Chen Charles J. Ryan Anthony Luke Robert U. Newton Imelda Tenggara Brooke Schultz Elizabeth Wang Emil Lavaki Kyle Zuniga Nicole Pinto Hala Borno Rahul Aggarwal Terence Friedlander Vadim S. Koshkin Andrea Harzstark Eric Small June M. Chan |
| author_facet | Stacey A. Kenfield Erin L. Van Blarigan Neil Panchal Alexander Bang Li Zhang Rebecca E. Graff Yea‐Hung Chen Charles J. Ryan Anthony Luke Robert U. Newton Imelda Tenggara Brooke Schultz Elizabeth Wang Emil Lavaki Kyle Zuniga Nicole Pinto Hala Borno Rahul Aggarwal Terence Friedlander Vadim S. Koshkin Andrea Harzstark Eric Small June M. Chan |
| author_sort | Stacey A. Kenfield |
| collection | DOAJ |
| description | Abstract Background Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC). Methods We conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high‐ and moderate‐intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based on attendance, adherence, and tolerance; safety on adverse events; and acceptability on participant interviews. Results Between March 2016 and March 2020, 25 patients were randomized (8 aerobic, 7 resistance, and 10 control). Twenty‐three men (82%) completed the 12‐week study. Men who completed the remote intervention attempted 90% and 96% of prescribed aerobic and resistance training sessions, respectively, and 86% and 88% of attempted sessions were completed as or more than prescribed. We observed changes in performance tests that corresponded with the exercise prescription. No safety concerns were identified. Ninety percent of participants interviewed were satisfied with the program and would recommend it to others. Conclusions Remotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer. |
| first_indexed | 2024-04-11T20:45:23Z |
| format | Article |
| id | doaj.art-982224bbcd1e4eb59b14dd6c2b73ea74 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-11T20:45:23Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-982224bbcd1e4eb59b14dd6c2b73ea742022-12-22T04:04:04ZengWileyCancer Medicine2045-76342021-11-0110228058807010.1002/cam4.4324Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancerStacey A. Kenfield0Erin L. Van Blarigan1Neil Panchal2Alexander Bang3Li Zhang4Rebecca E. Graff5Yea‐Hung Chen6Charles J. Ryan7Anthony Luke8Robert U. Newton9Imelda Tenggara10Brooke Schultz11Elizabeth Wang12Emil Lavaki13Kyle Zuniga14Nicole Pinto15Hala Borno16Rahul Aggarwal17Terence Friedlander18Vadim S. Koshkin19Andrea Harzstark20Eric Small21June M. Chan22University of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAEdith Cowan University Perth AustraliaUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAColumbia University New York New York USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAKaiser Permanente Oakland Medical Center Oakland California USAUniversity of California, San Francisco San Francisco California USAUniversity of California, San Francisco San Francisco California USAAbstract Background Exercise may improve clinical and quality of life outcomes for men with prostate cancer. No randomized controlled trials (RCTs) have examined the feasibility, safety, and acceptability of remote exercise training in men with metastatic castrate‐resistant prostate cancer (mCRPC). Methods We conducted a pilot RCT (1:1:1 aerobic or resistance exercise 3x/week or usual care) to determine the feasibility, safety, and acceptability of remotely monitored exercise over 12 weeks in 25 men with mCRPC. A prescribed exercise program was based on baseline testing including high‐ and moderate‐intensity aerobic exercise or resistance exercise completed at a local exercise facility. Feasibility was based on attendance, adherence, and tolerance; safety on adverse events; and acceptability on participant interviews. Results Between March 2016 and March 2020, 25 patients were randomized (8 aerobic, 7 resistance, and 10 control). Twenty‐three men (82%) completed the 12‐week study. Men who completed the remote intervention attempted 90% and 96% of prescribed aerobic and resistance training sessions, respectively, and 86% and 88% of attempted sessions were completed as or more than prescribed. We observed changes in performance tests that corresponded with the exercise prescription. No safety concerns were identified. Ninety percent of participants interviewed were satisfied with the program and would recommend it to others. Conclusions Remotely monitored exercise training is feasible, safe, and acceptable in men with mCRPC; there was no difference in these outcomes by mode of exercise. Through this research, we provide direction and rationale for future studies of exercise and clinical outcomes in patients with metastatic prostate cancer.https://doi.org/10.1002/cam4.4324behavioral interventionphysical activityremotestrength training |
| spellingShingle | Stacey A. Kenfield Erin L. Van Blarigan Neil Panchal Alexander Bang Li Zhang Rebecca E. Graff Yea‐Hung Chen Charles J. Ryan Anthony Luke Robert U. Newton Imelda Tenggara Brooke Schultz Elizabeth Wang Emil Lavaki Kyle Zuniga Nicole Pinto Hala Borno Rahul Aggarwal Terence Friedlander Vadim S. Koshkin Andrea Harzstark Eric Small June M. Chan Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer Cancer Medicine behavioral intervention physical activity remote strength training |
| title | Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer |
| title_full | Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer |
| title_fullStr | Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer |
| title_full_unstemmed | Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer |
| title_short | Feasibility, safety, and acceptability of a remotely monitored exercise pilot CHAMP: A Clinical trial of High‐intensity Aerobic and resistance exercise for Metastatic castrate‐resistant Prostate cancer |
| title_sort | feasibility safety and acceptability of a remotely monitored exercise pilot champ a clinical trial of high intensity aerobic and resistance exercise for metastatic castrate resistant prostate cancer |
| topic | behavioral intervention physical activity remote strength training |
| url | https://doi.org/10.1002/cam4.4324 |
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