Beta herpes viruses in patients with cutaneous graft-versus-host disease
Graft-versus-host disease is a major complication of allogenic bone marrow transplantation. Beta herpes viruses’ role in pathogenesis and prognosis of graft-versus-host disease is significant. Objective: To study beta herpes viruses evidence in skin biopsy specimens in graft-versus-host disease pati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2015-07-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/399 |
| Summary: | Graft-versus-host disease is a major complication of allogenic bone marrow transplantation. Beta herpes viruses’ role in pathogenesis and prognosis of graft-versus-host disease is significant. Objective: To study beta herpes viruses evidence in skin biopsy specimens in graft-versus-host disease patients. Material and methods: Clinical features of 50 patients with cutaneous graft-versus-host disease were examined. Cytomegalovirus and human herpes virus 6 DNA detection in skin biopsy specimens was performed by PCR. Results: Correlation between human herpes virus 6 and poor prognosis in graft-versus-host disease patients has been found. Conclusion: Beta herpes virus detection after allogenic bone marrow transplantation could be important in prognosis of graft-versus-host disease. |
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| ISSN: | 2072-6732 |