Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.

Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.

Diabetes mellitus leads to vascular complications but the underlying signalling mechanisms are not fully understood. Here, we examined the role of ErbB2 (HER2/Neu), a transmembrane receptor tyrosine kinase of the ErbB/EGFR (epidermal growth factor receptor) family, in mediating diabetes-induced vasc...

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Bibliographic Details
Main Authors: Saghir Akhtar, Mariam H M Yousif, Gursev S Dhaunsi, Fatma Sarkhouh, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3694874?pdf=render

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http://europepmc.org/articles/PMC3694874?pdf=render

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