Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis
Cyanobacteria, are only Gram-negative bacteria with the capacity of oxygenic photosynthesis, so termed as “Cyanophyta” or “blue-green algae.” Their habitat is ubiquitous, which includes the diverse environments, such as soil, water, rock and other organisms (symbiosis, commensalism, or parasitism, e...
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| Format: | Article |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00604/full |
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| author | Nguyen Huy Thuan Tran Tuan An Anil Shrestha Nguyen Xuan Canh Jae Kyung Sohng Jae Kyung Sohng Dipesh Dhakal |
| author_facet | Nguyen Huy Thuan Tran Tuan An Anil Shrestha Nguyen Xuan Canh Jae Kyung Sohng Jae Kyung Sohng Dipesh Dhakal |
| author_sort | Nguyen Huy Thuan |
| collection | DOAJ |
| description | Cyanobacteria, are only Gram-negative bacteria with the capacity of oxygenic photosynthesis, so termed as “Cyanophyta” or “blue-green algae.” Their habitat is ubiquitous, which includes the diverse environments, such as soil, water, rock and other organisms (symbiosis, commensalism, or parasitism, etc.,). They are characterized as prominent producers of numerous types of important compounds with anti-microbial, anti-viral, anti-inflammatory and anti-tumor properties. Among the various cyanobacterial genera, members belonging to genera Nostoc, Lyngbya, and Microcystis possess greater attention. The major reason for that is the strains belonging to these genera produce the compounds with diverse activities/structures, including compounds in preclinical and/or clinical trials (cryptophycin and curacin), or the compounds retaining unique activities such as protease inhibitor (micropeptins and aeruginosins). Most of these compounds were tested for their efficacy and mechanism of action(MOA) through in vitro and/or in vivo studies. Recently, the advances in culture techniques of these cyanobacteria, and isolation, purification, and chromatographic analysis of their compounds have revealed insurmountable novel bioactive compounds from these cyanobacteria. This review provides comprehensive update on the origin, isolation and purification methods, chemical structures and biological activities of the major compounds from Nostoc, Lyngbya, and Microcystis. In addition, multi-omics approaches and biotechnological production of compounds from selected cyanobacterial genera have been discussed. |
| first_indexed | 2024-12-21T17:10:00Z |
| format | Article |
| id | doaj.art-982a97b0f04a42f7aa709ee21ac84dc3 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-21T17:10:00Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-982a97b0f04a42f7aa709ee21ac84dc32022-12-21T18:56:25ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-09-01710.3389/fchem.2019.00604474915Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and MicrocystisNguyen Huy Thuan0Tran Tuan An1Anil Shrestha2Nguyen Xuan Canh3Jae Kyung Sohng4Jae Kyung Sohng5Dipesh Dhakal6Center for Molecular Biology, Institute of Research and Development, Duy Tan University, Danang, VietnamCenter for Molecular Biology, Institute of Research and Development, Duy Tan University, Danang, VietnamDepartment of Life Science and Biochemical Engineering, Sun Moon University, Chungnam, South KoreaFaculty of Biotechnology, Vietnam National University of Agriculture, Gialam, Hanoi, VietnamDepartment of Life Science and Biochemical Engineering, Sun Moon University, Chungnam, South KoreaDepartment of BT-Convergent Pharmaceutical Engineering, Sun Moon University, Chungnam, South KoreaDepartment of Life Science and Biochemical Engineering, Sun Moon University, Chungnam, South KoreaCyanobacteria, are only Gram-negative bacteria with the capacity of oxygenic photosynthesis, so termed as “Cyanophyta” or “blue-green algae.” Their habitat is ubiquitous, which includes the diverse environments, such as soil, water, rock and other organisms (symbiosis, commensalism, or parasitism, etc.,). They are characterized as prominent producers of numerous types of important compounds with anti-microbial, anti-viral, anti-inflammatory and anti-tumor properties. Among the various cyanobacterial genera, members belonging to genera Nostoc, Lyngbya, and Microcystis possess greater attention. The major reason for that is the strains belonging to these genera produce the compounds with diverse activities/structures, including compounds in preclinical and/or clinical trials (cryptophycin and curacin), or the compounds retaining unique activities such as protease inhibitor (micropeptins and aeruginosins). Most of these compounds were tested for their efficacy and mechanism of action(MOA) through in vitro and/or in vivo studies. Recently, the advances in culture techniques of these cyanobacteria, and isolation, purification, and chromatographic analysis of their compounds have revealed insurmountable novel bioactive compounds from these cyanobacteria. This review provides comprehensive update on the origin, isolation and purification methods, chemical structures and biological activities of the major compounds from Nostoc, Lyngbya, and Microcystis. In addition, multi-omics approaches and biotechnological production of compounds from selected cyanobacterial genera have been discussed.https://www.frontiersin.org/article/10.3389/fchem.2019.00604/fullCyanobacteriaNostocLyngbyaMicrocystisbioactive compoundsmulti-omics approaches |
| spellingShingle | Nguyen Huy Thuan Tran Tuan An Anil Shrestha Nguyen Xuan Canh Jae Kyung Sohng Jae Kyung Sohng Dipesh Dhakal Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis Frontiers in Chemistry Cyanobacteria Nostoc Lyngbya Microcystis bioactive compounds multi-omics approaches |
| title | Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis |
| title_full | Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis |
| title_fullStr | Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis |
| title_full_unstemmed | Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis |
| title_short | Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis |
| title_sort | recent advances in exploration and biotechnological production of bioactive compounds in three cyanobacterial genera nostoc lyngbya and microcystis |
| topic | Cyanobacteria Nostoc Lyngbya Microcystis bioactive compounds multi-omics approaches |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00604/full |
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