Questionable robustness in the findings of a meta-analysis
Marchand and colleagues conducted a meta-analysis examining COVID vaccine effects on all-cause and cardiac-related mortality. Findings aligned with previous research, showing no association with all-cause mortality. However, cardiac-related mortality exhibited a 6% increase post-vaccination. Concern...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-08-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2023.2253959 |
| _version_ | 1827767381567471616 |
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| author | Borja Somovilla Del Saz |
| author_facet | Borja Somovilla Del Saz |
| author_sort | Borja Somovilla Del Saz |
| collection | DOAJ |
| description | Marchand and colleagues conducted a meta-analysis examining COVID vaccine effects on all-cause and cardiac-related mortality. Findings aligned with previous research, showing no association with all-cause mortality. However, cardiac-related mortality exhibited a 6% increase post-vaccination. Concerns arise from reliance on a non-peer-reviewed study (Ladapo, 2022) influencing results significantly. Sensitivity analyses were lacking, undermining result robustness, particularly in gender-specific outcomes. Adherence to PRISMA guidelines for transparency and thoroughness could strengthen conclusions. This study underscores vaccine safety scrutiny, yet the influence of biased sources and absence of sensitivity testing warrant careful consideration. |
| first_indexed | 2024-03-11T11:57:56Z |
| format | Article |
| id | doaj.art-982ab4cba6d64aa0b58ecf9b2266d0f0 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T11:57:56Z |
| publishDate | 2023-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-982ab4cba6d64aa0b58ecf9b2266d0f02023-11-08T11:55:20ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-08-0119210.1080/21645515.2023.22539592253959Questionable robustness in the findings of a meta-analysisBorja Somovilla Del Saz0University of Valencia (ETSE)Marchand and colleagues conducted a meta-analysis examining COVID vaccine effects on all-cause and cardiac-related mortality. Findings aligned with previous research, showing no association with all-cause mortality. However, cardiac-related mortality exhibited a 6% increase post-vaccination. Concerns arise from reliance on a non-peer-reviewed study (Ladapo, 2022) influencing results significantly. Sensitivity analyses were lacking, undermining result robustness, particularly in gender-specific outcomes. Adherence to PRISMA guidelines for transparency and thoroughness could strengthen conclusions. This study underscores vaccine safety scrutiny, yet the influence of biased sources and absence of sensitivity testing warrant careful consideration.http://dx.doi.org/10.1080/21645515.2023.2253959meta-analysisall-cause mortalitycardiac-related mortalitycovid vaccinescovid-19 |
| spellingShingle | Borja Somovilla Del Saz Questionable robustness in the findings of a meta-analysis Human Vaccines & Immunotherapeutics meta-analysis all-cause mortality cardiac-related mortality covid vaccines covid-19 |
| title | Questionable robustness in the findings of a meta-analysis |
| title_full | Questionable robustness in the findings of a meta-analysis |
| title_fullStr | Questionable robustness in the findings of a meta-analysis |
| title_full_unstemmed | Questionable robustness in the findings of a meta-analysis |
| title_short | Questionable robustness in the findings of a meta-analysis |
| title_sort | questionable robustness in the findings of a meta analysis |
| topic | meta-analysis all-cause mortality cardiac-related mortality covid vaccines covid-19 |
| url | http://dx.doi.org/10.1080/21645515.2023.2253959 |
| work_keys_str_mv | AT borjasomovilladelsaz questionablerobustnessinthefindingsofametaanalysis |