Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms
Purpose: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom Score. Materials and Methods: A total of 412 men underwent testostero...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2018-11-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-59-399.pdf |
| _version_ | 1818515569959239680 |
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| author | Farid Saad Gheorghe Doros Karim Sultan Haider Ahmad Haider |
| author_facet | Farid Saad Gheorghe Doros Karim Sultan Haider Ahmad Haider |
| author_sort | Farid Saad |
| collection | DOAJ |
| description | Purpose: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom Score. Materials and Methods: A total of 412 men underwent testosterone therapy (TTh) with injectable testosterone undecanoate, 393 men served as untreated controls. Measures of urinary function, anthropometric and metabolic parameters were performed at least twice per year. Results: Data from 615 men with mild LUTS (253 treated, 362 untreated) and 190 with moderate-to-severe LUTS (159 treated, 31 untreated) were available. During a follow-up period of 8 years a significant improvement of LUTS was noted for all TTh-patients whereas the control-groups showed deterioration or fluctuation around initial values. Despite advancing age, TTh fully prevented worsening of symptoms. In parallel, a considerable improvement of anthropometric parameters, lipids and glycemic control, blood pressure, C-reactive protein, and quality of life was found. Moderate-to-severe LUTS was associated with worse cardiometabolic risk profile at baseline as well as worse cardiovascular outcomes during follow-up in comparison to mild LUTS. Effect size of TTh was more pronounced in men with moderate-to-severe than with mild LUTS. Conclusions: Correcting hypogonadism by TTh is highly effective and safe for improving LUTS in hypogonadal men. TTh may also improve cardiometabolic risk and major adverse cardiovascular events. |
| first_indexed | 2024-12-11T00:30:35Z |
| format | Article |
| id | doaj.art-982af7238922471e8f41613c2ad1abe7 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-11T00:30:35Z |
| publishDate | 2018-11-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-982af7238922471e8f41613c2ad1abe72022-12-22T01:27:21ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2018-11-0159639940910.4111/icu.2018.59.6.399Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptomsFarid Saad0Gheorghe Doros1Karim Sultan Haider2Ahmad Haider3Global Medical Affairs Andrology, Bayer AG, Berlin, GermanyDepartment of Epidemiology and Statistics, Boston University School of Public Health, Boston, MA, USAPrivate Urology Practice, Bremerhaven, GermanyPrivate Urology Practice, Bremerhaven, GermanyPurpose: To analyze data from an observational, prospective, cumulative registry study in 805 hypogonadal men stratified by mild or moderate-to-severe lower urinary tract symptoms (LUTS) according to International Prostate Symptom Score. Materials and Methods: A total of 412 men underwent testosterone therapy (TTh) with injectable testosterone undecanoate, 393 men served as untreated controls. Measures of urinary function, anthropometric and metabolic parameters were performed at least twice per year. Results: Data from 615 men with mild LUTS (253 treated, 362 untreated) and 190 with moderate-to-severe LUTS (159 treated, 31 untreated) were available. During a follow-up period of 8 years a significant improvement of LUTS was noted for all TTh-patients whereas the control-groups showed deterioration or fluctuation around initial values. Despite advancing age, TTh fully prevented worsening of symptoms. In parallel, a considerable improvement of anthropometric parameters, lipids and glycemic control, blood pressure, C-reactive protein, and quality of life was found. Moderate-to-severe LUTS was associated with worse cardiometabolic risk profile at baseline as well as worse cardiovascular outcomes during follow-up in comparison to mild LUTS. Effect size of TTh was more pronounced in men with moderate-to-severe than with mild LUTS. Conclusions: Correcting hypogonadism by TTh is highly effective and safe for improving LUTS in hypogonadal men. TTh may also improve cardiometabolic risk and major adverse cardiovascular events.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-59-399.pdfCardiovascular diseasesLower urinary tract symptomsMetabolic syndromeQuality of lifeTestosterone |
| spellingShingle | Farid Saad Gheorghe Doros Karim Sultan Haider Ahmad Haider Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms Investigative and Clinical Urology Cardiovascular diseases Lower urinary tract symptoms Metabolic syndrome Quality of life Testosterone |
| title | Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms |
| title_full | Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms |
| title_fullStr | Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms |
| title_full_unstemmed | Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms |
| title_short | Hypogonadal men with moderate-to-severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms |
| title_sort | hypogonadal men with moderate to severe lower urinary tract symptoms have a more severe cardiometabolic risk profile and benefit more from testosterone therapy than men with mild lower urinary tract symptoms |
| topic | Cardiovascular diseases Lower urinary tract symptoms Metabolic syndrome Quality of life Testosterone |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-59-399.pdf |
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