Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation
Purpose The aim of this study was to define the capsules of synchronous multicentric small hepatocellular carcinomas (HCCs) with use of high-frequency intraoperative ultrasonography (IOUS). Methods Among the 131 consecutive patients undergoing hepatic resection and high-frequency IOUS for HCC, 16 sy...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2016-10-01
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| Series: | Ultrasonography |
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| Online Access: | http://e-ultrasonography.org/upload/usg-16001.pdf |
| _version_ | 1818853080174690304 |
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| author | Jae Hong Ahn Dae-Woon Eom Dae Shick Ryu Man Soo Park Seung Mun Jung Kun Moo Choi Gab Jin Cheon Soo-Jung Choi Hyuk Jai Jang |
| author_facet | Jae Hong Ahn Dae-Woon Eom Dae Shick Ryu Man Soo Park Seung Mun Jung Kun Moo Choi Gab Jin Cheon Soo-Jung Choi Hyuk Jai Jang |
| author_sort | Jae Hong Ahn |
| collection | DOAJ |
| description | Purpose The aim of this study was to define the capsules of synchronous multicentric small hepatocellular carcinomas (HCCs) with use of high-frequency intraoperative ultrasonography (IOUS). Methods Among the 131 consecutive patients undergoing hepatic resection and high-frequency IOUS for HCC, 16 synchronous multicentric small HCCs in 13 patients were histologically diagnosed in the resected specimens. High-frequency IOUS and pathologic findings of these lesions were compared, with particular focus on the presence and appearance of the capsule in or around each lesion. Results Synchronous multicentric small HCCs were pathologically classified into distinctly nodular (n=12) or vaguely nodular (n=4) types. All 12 distinctly nodular HCCs including six subcentimeter lesions showed detectable capsules on high-frequency IOUS and pathology. The capsules appeared as a hypoechoic rim containing hyperechoic foci (n=6), hypoechoic rim (n=5), or hyperechoic rim (n=1) with varying degrees of coverage around each lesion. Histologically, the capsules were composed of a combination of one to four layers consisting of a fibrous capsule, peritumoral fibrosis, prominent small vessels, and entrapped hepatic parenchyma. Conclusion Synchronous multicentric small HCCs with distinctly nodular type, even at subcentimeter size, can show capsules with varying coverage and diverse echogenicity on high-frequency IOUS. |
| first_indexed | 2024-12-19T07:31:07Z |
| format | Article |
| id | doaj.art-982b43156c614a28a1d3ff80b386e38a |
| institution | Directory Open Access Journal |
| issn | 2288-5919 2288-5943 |
| language | English |
| last_indexed | 2024-12-19T07:31:07Z |
| publishDate | 2016-10-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-982b43156c614a28a1d3ff80b386e38a2022-12-21T20:30:43ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59192288-59432016-10-0135433534410.14366/usg.16001132Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlationJae Hong Ahn0Dae-Woon Eom1Dae Shick Ryu2Man Soo Park3Seung Mun Jung4Kun Moo Choi5Gab Jin Cheon6Soo-Jung Choi7Hyuk Jai Jang8 Department of Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Pathology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Hepatology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Radiology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, KoreaPurpose The aim of this study was to define the capsules of synchronous multicentric small hepatocellular carcinomas (HCCs) with use of high-frequency intraoperative ultrasonography (IOUS). Methods Among the 131 consecutive patients undergoing hepatic resection and high-frequency IOUS for HCC, 16 synchronous multicentric small HCCs in 13 patients were histologically diagnosed in the resected specimens. High-frequency IOUS and pathologic findings of these lesions were compared, with particular focus on the presence and appearance of the capsule in or around each lesion. Results Synchronous multicentric small HCCs were pathologically classified into distinctly nodular (n=12) or vaguely nodular (n=4) types. All 12 distinctly nodular HCCs including six subcentimeter lesions showed detectable capsules on high-frequency IOUS and pathology. The capsules appeared as a hypoechoic rim containing hyperechoic foci (n=6), hypoechoic rim (n=5), or hyperechoic rim (n=1) with varying degrees of coverage around each lesion. Histologically, the capsules were composed of a combination of one to four layers consisting of a fibrous capsule, peritumoral fibrosis, prominent small vessels, and entrapped hepatic parenchyma. Conclusion Synchronous multicentric small HCCs with distinctly nodular type, even at subcentimeter size, can show capsules with varying coverage and diverse echogenicity on high-frequency IOUS.http://e-ultrasonography.org/upload/usg-16001.pdfLiver neoplasmsCarcinoma, hepatocellularUltrasonography |
| spellingShingle | Jae Hong Ahn Dae-Woon Eom Dae Shick Ryu Man Soo Park Seung Mun Jung Kun Moo Choi Gab Jin Cheon Soo-Jung Choi Hyuk Jai Jang Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation Ultrasonography Liver neoplasms Carcinoma, hepatocellular Ultrasonography |
| title | Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation |
| title_full | Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation |
| title_fullStr | Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation |
| title_full_unstemmed | Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation |
| title_short | Synchronous multicentric small hepatocellular carcinomas: defining the capsule on high-frequency intraoperative ultrasonography with pathologic correlation |
| title_sort | synchronous multicentric small hepatocellular carcinomas defining the capsule on high frequency intraoperative ultrasonography with pathologic correlation |
| topic | Liver neoplasms Carcinoma, hepatocellular Ultrasonography |
| url | http://e-ultrasonography.org/upload/usg-16001.pdf |
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