Double-layered N-S1 protein nanoparticle immunization elicits robust cellular immune and broad antibody responses against SARS-CoV-2

Double-layered N-S1 protein nanoparticle immunization elicits robust cellular immune and broad antibody responses against SARS-CoV-2

Abstract Background The COVID-19 pandemic is a persistent global threat to public health. As for the emerging variants of SARS-CoV-2, it is necessary to develop vaccines that can induce broader immune responses, particularly vaccines with weak cellular immunity. Methods In this study, we generated a...

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Bibliographic Details
Main Authors: Ruiqi Li, Zejie Chang, Hongliang Liu, Yanan Wang, Minghui Li, Yilan Chen, Lu Fan, Siqiao Wang, Xueke Sun, Siyuan Liu, Anchun Cheng, Peiyang Ding, Gaiping Zhang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Nanobiotechnology
Subjects:
COVID-19
Coronavirus
SARS-CoV-2
Nanoparticle
Subunit vaccine
Variants
Online Access:https://doi.org/10.1186/s12951-024-02293-y

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