Animal Models in Human Adenovirus Research
Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved antiadenoviral compounds are available to efficie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/12/1253 |
| _version_ | 1797506527314051072 |
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| author | Luca D. Bertzbach Wing-Hang Ip Thomas Dobner |
| author_facet | Luca D. Bertzbach Wing-Hang Ip Thomas Dobner |
| author_sort | Luca D. Bertzbach |
| collection | DOAJ |
| description | Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved antiadenoviral compounds are available to efficiently deal with HAdV infections. Thus, there is a need to thoroughly understand HAdV-induced disease, and for the development and preclinical evaluation of HAdV therapeutics and/or vaccines, and consequently for suitable standardizable in vitro systems and animal models. Current animal models to study HAdV pathogenesis, persistence, and tumorigenesis include rodents such as Syrian hamsters, mice, and cotton rats, as well as rabbits. In addition, a few recent studies on other species, such as pigs and tree shrews, reported promising data. These models mimic (aspects of) HAdV-induced pathological changes in humans and, although they are relevant, an ideal HAdV animal model has yet to be developed. This review summarizes the available animal models of HAdV infection with comprehensive descriptions of virus-induced pathogenesis in different animal species. We also elaborate on rodent HAdV animal models and how they contributed to insights into adenovirus-induced cell transformation and cancer. |
| first_indexed | 2024-03-10T04:34:54Z |
| format | Article |
| id | doaj.art-982c711d85a3475e898e658f79673f9b |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T04:34:54Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-982c711d85a3475e898e658f79673f9b2023-11-23T03:53:13ZengMDPI AGBiology2079-77372021-12-011012125310.3390/biology10121253Animal Models in Human Adenovirus ResearchLuca D. Bertzbach0Wing-Hang Ip1Thomas Dobner2Leibniz Institute for Experimental Virology (HPI), Martinistr. 52, 20251 Hamburg, GermanyLeibniz Institute for Experimental Virology (HPI), Martinistr. 52, 20251 Hamburg, GermanyLeibniz Institute for Experimental Virology (HPI), Martinistr. 52, 20251 Hamburg, GermanyHuman adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved antiadenoviral compounds are available to efficiently deal with HAdV infections. Thus, there is a need to thoroughly understand HAdV-induced disease, and for the development and preclinical evaluation of HAdV therapeutics and/or vaccines, and consequently for suitable standardizable in vitro systems and animal models. Current animal models to study HAdV pathogenesis, persistence, and tumorigenesis include rodents such as Syrian hamsters, mice, and cotton rats, as well as rabbits. In addition, a few recent studies on other species, such as pigs and tree shrews, reported promising data. These models mimic (aspects of) HAdV-induced pathological changes in humans and, although they are relevant, an ideal HAdV animal model has yet to be developed. This review summarizes the available animal models of HAdV infection with comprehensive descriptions of virus-induced pathogenesis in different animal species. We also elaborate on rodent HAdV animal models and how they contributed to insights into adenovirus-induced cell transformation and cancer.https://www.mdpi.com/2079-7737/10/12/1253cotton ratsexperimental infectionhuman adenovirus (HAdV)(humanized) micein vivo modelpigs |
| spellingShingle | Luca D. Bertzbach Wing-Hang Ip Thomas Dobner Animal Models in Human Adenovirus Research Biology cotton rats experimental infection human adenovirus (HAdV) (humanized) mice in vivo model pigs |
| title | Animal Models in Human Adenovirus Research |
| title_full | Animal Models in Human Adenovirus Research |
| title_fullStr | Animal Models in Human Adenovirus Research |
| title_full_unstemmed | Animal Models in Human Adenovirus Research |
| title_short | Animal Models in Human Adenovirus Research |
| title_sort | animal models in human adenovirus research |
| topic | cotton rats experimental infection human adenovirus (HAdV) (humanized) mice in vivo model pigs |
| url | https://www.mdpi.com/2079-7737/10/12/1253 |
| work_keys_str_mv | AT lucadbertzbach animalmodelsinhumanadenovirusresearch AT winghangip animalmodelsinhumanadenovirusresearch AT thomasdobner animalmodelsinhumanadenovirusresearch |