Buffering Adaptive Immunity by Hydrogen Sulfide
T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/325 |
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| author | Giulia Pozzi Giuliana Gobbi Elena Masselli Cecilia Carubbi Valentina Presta Luca Ambrosini Marco Vitale Prisco Mirandola |
| author_facet | Giulia Pozzi Giuliana Gobbi Elena Masselli Cecilia Carubbi Valentina Presta Luca Ambrosini Marco Vitale Prisco Mirandola |
| author_sort | Giulia Pozzi |
| collection | DOAJ |
| description | T cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H<sub>2</sub>S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H<sub>2</sub>S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H<sub>2</sub>S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H<sub>2</sub>S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses. |
| first_indexed | 2024-03-10T00:05:28Z |
| format | Article |
| id | doaj.art-982f55d05ffd40168560087f4add8547 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:05:28Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-982f55d05ffd40168560087f4add85472023-11-23T16:09:59ZengMDPI AGCells2073-44092022-01-0111332510.3390/cells11030325Buffering Adaptive Immunity by Hydrogen SulfideGiulia Pozzi0Giuliana Gobbi1Elena Masselli2Cecilia Carubbi3Valentina Presta4Luca Ambrosini5Marco Vitale6Prisco Mirandola7Anatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyAnatomy Unit, Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyT cell-mediated adaptive immunity is designed to respond to non-self antigens and pathogens through the activation and proliferation of various T cell populations. T helper 1 (Th1), Th2, Th17 and Treg cells finely orchestrate cellular responses through a plethora of paracrine and autocrine stimuli that include cytokines, autacoids, and hormones. Hydrogen sulfide (H<sub>2</sub>S) is one of these mediators able to induce/inhibit immunological responses, playing a role in inflammatory and autoimmune diseases, neurological disorders, asthma, acute pancreatitis, and sepsis. Both endogenous and exogenous H<sub>2</sub>S modulate numerous important cell signaling pathways. In monocytes, polymorphonuclear, and T cells H<sub>2</sub>S impacts on activation, survival, proliferation, polarization, adhesion pathways, and modulates cytokine production and sensitivity to chemokines. Here, we offer a comprehensive review on the role of H<sub>2</sub>S as a natural buffer able to maintain over time a functional balance between Th1, Th2, Th17 and Treg immunological responses.https://www.mdpi.com/2073-4409/11/3/325gasotransmittersNaHScystathionine-synthasecystathionine-lyasesulphurous waters |
| spellingShingle | Giulia Pozzi Giuliana Gobbi Elena Masselli Cecilia Carubbi Valentina Presta Luca Ambrosini Marco Vitale Prisco Mirandola Buffering Adaptive Immunity by Hydrogen Sulfide Cells gasotransmitters NaHS cystathionine-synthase cystathionine-lyase sulphurous waters |
| title | Buffering Adaptive Immunity by Hydrogen Sulfide |
| title_full | Buffering Adaptive Immunity by Hydrogen Sulfide |
| title_fullStr | Buffering Adaptive Immunity by Hydrogen Sulfide |
| title_full_unstemmed | Buffering Adaptive Immunity by Hydrogen Sulfide |
| title_short | Buffering Adaptive Immunity by Hydrogen Sulfide |
| title_sort | buffering adaptive immunity by hydrogen sulfide |
| topic | gasotransmitters NaHS cystathionine-synthase cystathionine-lyase sulphurous waters |
| url | https://www.mdpi.com/2073-4409/11/3/325 |
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