MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases
Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnmol.2020.00090/full |
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| author | Weihao Fan Weihao Fan Chunmei Liang Mingqian Ou Mingqian Ou Ting Zou Ting Zou Furong Sun Furong Sun Haihong Zhou Haihong Zhou Lili Cui |
| author_facet | Weihao Fan Weihao Fan Chunmei Liang Mingqian Ou Mingqian Ou Ting Zou Ting Zou Furong Sun Furong Sun Haihong Zhou Haihong Zhou Lili Cui |
| author_sort | Weihao Fan |
| collection | DOAJ |
| description | Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features, particularly the neuroinflammatory response in the nervous system. A rapidly growing body of evidence indicates that various microRNAs play pivotal roles in these processes in neurological diseases and might be viable therapeutic targets. Among these microRNAs, microRNA-146a (miR-146a) stands out due to the rapid increase in recent literature on its mechanistic involvement in neurological diseases. In this review, we summarize and highlight the critical role of miR-146a in neurological diseases. MiR-146a polymorphisms are associated with the risk of neurological disease. Alterations in miR-146a expression levels are crucial events in the pathogenesis of numerous neurological diseases that are spatially and temporally diverse. Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases. |
| first_indexed | 2024-04-13T16:59:43Z |
| format | Article |
| id | doaj.art-982f8ddacf2a4309bc71d35b7a09654c |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T16:59:43Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-982f8ddacf2a4309bc71d35b7a09654c2022-12-22T02:38:43ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992020-06-011310.3389/fnmol.2020.00090532957MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological DiseasesWeihao Fan0Weihao Fan1Chunmei Liang2Mingqian Ou3Mingqian Ou4Ting Zou5Ting Zou6Furong Sun7Furong Sun8Haihong Zhou9Haihong Zhou10Lili Cui11Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, ChinaProgressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features, particularly the neuroinflammatory response in the nervous system. A rapidly growing body of evidence indicates that various microRNAs play pivotal roles in these processes in neurological diseases and might be viable therapeutic targets. Among these microRNAs, microRNA-146a (miR-146a) stands out due to the rapid increase in recent literature on its mechanistic involvement in neurological diseases. In this review, we summarize and highlight the critical role of miR-146a in neurological diseases. MiR-146a polymorphisms are associated with the risk of neurological disease. Alterations in miR-146a expression levels are crucial events in the pathogenesis of numerous neurological diseases that are spatially and temporally diverse. Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases.https://www.frontiersin.org/article/10.3389/fnmol.2020.00090/fullmicroRNA-146aneurological diseasessingle-nucleotide polymorphismsneuroinflammationbiomarker |
| spellingShingle | Weihao Fan Weihao Fan Chunmei Liang Mingqian Ou Mingqian Ou Ting Zou Ting Zou Furong Sun Furong Sun Haihong Zhou Haihong Zhou Lili Cui MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases Frontiers in Molecular Neuroscience microRNA-146a neurological diseases single-nucleotide polymorphisms neuroinflammation biomarker |
| title | MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases |
| title_full | MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases |
| title_fullStr | MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases |
| title_full_unstemmed | MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases |
| title_short | MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases |
| title_sort | microrna 146a is a wide reaching neuroinflammatory regulator and potential treatment target in neurological diseases |
| topic | microRNA-146a neurological diseases single-nucleotide polymorphisms neuroinflammation biomarker |
| url | https://www.frontiersin.org/article/10.3389/fnmol.2020.00090/full |
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