Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses
The objective of this study was to compare the hemodynamic effects of dobutamine and ephedrine during the management of anesthesia-related hypotension in healthy horses. Thirteen horses underwent general anesthesia with isoflurane and were randomly divided into two different groups, one of which rec...
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MDPI AG
2023-04-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/4/278 |
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| author | Sergio Grandisoli Garcia Filho Felipe Silveira Rego Monteiro de Andrade Rosana Souza Thurler dos Santos Lucas Alaião Gonçalves Marco Aurélio Amador Pereira Anderson Fernando de Souza Aline Magalhães Ambrósio Denise Tabacchi Fantoni |
| author_facet | Sergio Grandisoli Garcia Filho Felipe Silveira Rego Monteiro de Andrade Rosana Souza Thurler dos Santos Lucas Alaião Gonçalves Marco Aurélio Amador Pereira Anderson Fernando de Souza Aline Magalhães Ambrósio Denise Tabacchi Fantoni |
| author_sort | Sergio Grandisoli Garcia Filho |
| collection | DOAJ |
| description | The objective of this study was to compare the hemodynamic effects of dobutamine and ephedrine during the management of anesthesia-related hypotension in healthy horses. Thirteen horses underwent general anesthesia with isoflurane and were randomly divided into two different groups, one of which received a dobutamine constant rate infusion (CRI) (1 µg/kg bwt/min) and the other received an ephedrine CRI (20 µg/kg bwt/min) when hypotension (<60 mmHg) was identified, following up to 15 min after the blood pressure reached 70 mmHg. All horses were equipped with a pulmonary artery catheter and a peripheral artery catheter, and multiparameter monitoring commenced as soon as they were under mechanical ventilation. Hemodynamic parameters were recorded, while tissue perfusion markers (peripheral oxygen saturation, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, arterial pH, arterial plasma bicarbonate concentration, arterial oxygen saturation, mixed venous oxygen saturation, mixed venous oxygen content, arterial oxygen content, arteriovenous oxygen difference, oxygen delivery index, oxygen consumption index, and oxygen extraction ratio), serum lactate concentration, and troponin I concentrations were analyzed before the start of infusions (T0), when the blood pressure reached 70 mmHg (T1), and 15 min after T1 (T2). The time to restore the arterial pressure was similar in both groups (<i>p</i> > 0.05); however, the heart rate was higher in the ephedrine group (<i>p</i> = 0.0098), and sinus bradyarrhythmia occurred in the dobutamine group. Furthermore, both experimental protocols increased cardiac output (<i>p</i> = 0.0012), cardiac index (<i>p</i> = 0.0013), systemic vascular resistance (<i>p</i> = 0.008), systemic vascular resistance index (<i>p</i> < 0.001), and ameliorated perfusion markers. In the dobutamine group, the pulmonary artery wedge pressure (<i>p</i> < 0.001) and systolic index (<i>p</i> = 0.003) were elevated, while the arteriovenous oxygen difference was reduced in the ephedrine group (<i>p</i> = 0.02). Troponin I was used as a myocardial injury indicator, and did not differ between moments or between groups (<i>p</i> > 0.05). We concluded that both drugs were effective and safe to treat anesthetic hypotension under the conditions of this study. |
| first_indexed | 2024-03-11T04:27:20Z |
| format | Article |
| id | doaj.art-983134cb27a84a56967154bc4da9d882 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T04:27:20Z |
| publishDate | 2023-04-01 |
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| series | Veterinary Sciences |
| spelling | doaj.art-983134cb27a84a56967154bc4da9d8822023-11-17T21:43:41ZengMDPI AGVeterinary Sciences2306-73812023-04-0110427810.3390/vetsci10040278Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized HorsesSergio Grandisoli Garcia Filho0Felipe Silveira Rego Monteiro de Andrade1Rosana Souza Thurler dos Santos2Lucas Alaião Gonçalves3Marco Aurélio Amador Pereira4Anderson Fernando de Souza5Aline Magalhães Ambrósio6Denise Tabacchi Fantoni7Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilDepartment of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, 87 Professor Orlando Marques Paiva Ave., São Paulo 05508-270, SP, BrazilThe objective of this study was to compare the hemodynamic effects of dobutamine and ephedrine during the management of anesthesia-related hypotension in healthy horses. Thirteen horses underwent general anesthesia with isoflurane and were randomly divided into two different groups, one of which received a dobutamine constant rate infusion (CRI) (1 µg/kg bwt/min) and the other received an ephedrine CRI (20 µg/kg bwt/min) when hypotension (<60 mmHg) was identified, following up to 15 min after the blood pressure reached 70 mmHg. All horses were equipped with a pulmonary artery catheter and a peripheral artery catheter, and multiparameter monitoring commenced as soon as they were under mechanical ventilation. Hemodynamic parameters were recorded, while tissue perfusion markers (peripheral oxygen saturation, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, arterial pH, arterial plasma bicarbonate concentration, arterial oxygen saturation, mixed venous oxygen saturation, mixed venous oxygen content, arterial oxygen content, arteriovenous oxygen difference, oxygen delivery index, oxygen consumption index, and oxygen extraction ratio), serum lactate concentration, and troponin I concentrations were analyzed before the start of infusions (T0), when the blood pressure reached 70 mmHg (T1), and 15 min after T1 (T2). The time to restore the arterial pressure was similar in both groups (<i>p</i> > 0.05); however, the heart rate was higher in the ephedrine group (<i>p</i> = 0.0098), and sinus bradyarrhythmia occurred in the dobutamine group. Furthermore, both experimental protocols increased cardiac output (<i>p</i> = 0.0012), cardiac index (<i>p</i> = 0.0013), systemic vascular resistance (<i>p</i> = 0.008), systemic vascular resistance index (<i>p</i> < 0.001), and ameliorated perfusion markers. In the dobutamine group, the pulmonary artery wedge pressure (<i>p</i> < 0.001) and systolic index (<i>p</i> = 0.003) were elevated, while the arteriovenous oxygen difference was reduced in the ephedrine group (<i>p</i> = 0.02). Troponin I was used as a myocardial injury indicator, and did not differ between moments or between groups (<i>p</i> > 0.05). We concluded that both drugs were effective and safe to treat anesthetic hypotension under the conditions of this study.https://www.mdpi.com/2306-7381/10/4/278hypotensionsympathomimeticscardiac outputvasoactiveinotropic |
| spellingShingle | Sergio Grandisoli Garcia Filho Felipe Silveira Rego Monteiro de Andrade Rosana Souza Thurler dos Santos Lucas Alaião Gonçalves Marco Aurélio Amador Pereira Anderson Fernando de Souza Aline Magalhães Ambrósio Denise Tabacchi Fantoni Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses Veterinary Sciences hypotension sympathomimetics cardiac output vasoactive inotropic |
| title | Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses |
| title_full | Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses |
| title_fullStr | Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses |
| title_full_unstemmed | Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses |
| title_short | Comparison of Hemodynamic Effects of Dobutamine and Ephedrine Infusions in Isoflurane-Anesthetized Horses |
| title_sort | comparison of hemodynamic effects of dobutamine and ephedrine infusions in isoflurane anesthetized horses |
| topic | hypotension sympathomimetics cardiac output vasoactive inotropic |
| url | https://www.mdpi.com/2306-7381/10/4/278 |
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